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1. WO2006100204 - BENZAMIDINE DERIVATIVES FOR TREATMENT AND PREVENTION OF CANCER THERAPY INDUCED MUCOSITIS

Publication Number WO/2006/100204
Publication Date 28.09.2006
International Application No. PCT/EP2006/060789
International Filing Date 16.03.2006
Chapter 2 Demand Filed 22.12.2006
IPC
A61K 31/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group N-C(O)-N or N-C(S)-N, e.g. urea, thiourea, carmustine
A61P 1/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
CPC
A61K 31/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Applicants
  • ROTTAPHARM S.p.A. [IT]/[IT] (AllExceptUS)
  • LETARI, Ornella [IT]/[IT] (UsOnly)
  • D'AMATO, Massimo Maria [IT]/[IT] (UsOnly)
  • ZANZOLA, Simona [IT]/[IT] (UsOnly)
  • ARTUSI, Roberto [IT]/[IT] (UsOnly)
  • ROVATI, Lucio Claudio [IT]/[IT] (UsOnly)
  • CASELLI, Gianfranco [IT]/[IT] (UsOnly)
  • GIORDANI, Antonio [IT]/[IT] (UsOnly)
Inventors
  • LETARI, Ornella
  • D'AMATO, Massimo Maria
  • ZANZOLA, Simona
  • ARTUSI, Roberto
  • ROVATI, Lucio Claudio
  • CASELLI, Gianfranco
  • GIORDANI, Antonio
Agents
  • RAMBELLI, Paolo
Priority Data
05102423.024.03.2005EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BENZAMIDINE DERIVATIVES FOR TREATMENT AND PREVENTION OF CANCER THERAPY INDUCED MUCOSITIS
(FR) DERIVES DE BENZAMIDINE POUR LE TRAITEMENT ET LA PREVENTION DES MUCOSITES PROVOQUEES PAR LES TRAITEMENTS ANTICANCEREUX
Abstract
(EN)
Mucositis is the result of a complex process of interactive biologic phenomena that take place in both the epitelium and the submucosa, often leading to severe pain and increased risk of dangerous systemic infections. Mucositis is often a side effect during chemotherapy and radiation therapy. The benzamidine derivatives herein described are particularly effective for treating and preventing mucositis since they are acting simultaneously at the several phases that characterize this disease.
(FR)
La mucosite est le résultat d'un processus complexe de phénomènes biologiques interactifs se produisant à la fois dans l'épithélium et dans la sous-muqueuse, et entraîne souvent des douleurs importantes et un risque accru de contracter des infections systémiques dangereuses. La mucosite est souvent un effet secondaire des traitements de chimiothérapie et de radiothérapie. Les dérivés de benzamidine faisant l'objet de la présente invention sont particulièrement efficaces pour le traitement et la prévention des mucosites du fait qu'il agissent à la fois dans toutes les différentes phases caractérisant cette maladie.
Latest bibliographic data on file with the International Bureau