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1. WO2006099651 - LIQUID AQUEOUS DOSAGE FORMS FOR SUB-LINGUAL OR NASAL APPLICATIONS OF ACTIVE AGENTS WITH AMINO GROUPS

Publication Number WO/2006/099651
Publication Date 28.09.2006
International Application No. PCT/AT2006/000126
International Filing Date 24.03.2006
IPC
A61K 9/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 31/167 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
167having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/135 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
A61K 31/485 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
485Morphinan derivatives, e.g. morphine, codeine
A61K 31/465 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
465Nicotine; Derivatives thereof
CPC
A61K 31/135
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
135having aromatic rings ; , e.g. ketamine, nortriptyline
A61K 31/167
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
167having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/465
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
465Nicotine; Derivatives thereof
A61K 31/485
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
485Morphinan derivatives, e.g. morphine, codeine
A61K 9/0043
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0043Nose
A61K 9/006
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
Applicants
  • UNIPACK GES.M.B.H. [AT]/[AT] (AllExceptUS)
  • BURGHART, Kurt [AT]/[AT] (UsOnly)
  • BURGHART, Walter [AT]/[AT] (UsOnly)
Inventors
  • BURGHART, Kurt
  • BURGHART, Walter
Agents
  • HAFFNER, Thomas, M.
Priority Data
A 512/200524.03.2005AT
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) FLÜSSIGE, WÄSSRIGE DARREICHUNGSFORM FÜR SUBLINGUALE ODER NASALE ANWENDUNGEN VON AMINORGRUPPEN AUFWEISENDEN WIRKSTOFFEN
(EN) LIQUID AQUEOUS DOSAGE FORMS FOR SUB-LINGUAL OR NASAL APPLICATIONS OF ACTIVE AGENTS WITH AMINO GROUPS
(FR) FORME GALENIQUE AQUEUSE LIQUIDE POUR APPLICATIONS SUBLINGUALES OU NASALES DE PRINCIPES ACTIFS PRESENTANT DES GROUPES AMINO
Abstract
(DE)
Bei einer flüssigen, wässrigen Darreichungsform für sublinguale oder nasale Anwendungen von Aminogruppen aufwiesenden Wirkstoffen, wie z. B. von Analgetika, insbesondere Opiate, Lokalanästhetika, Antihistaminika oder Nicotin, ist der Wirkstoff als pharmakologisch unbedenkliches Salz eingesetzt und liegt mit K-Sorbat in wenigstens äquimolarer Menge in der Flüssigkeit vor.
(EN)
The invention relates to a liquid aqueous dosage form for sub-lingual or nasal applications of active agents with amino groups, such as for example, analgesics, in particular, opiates, local anesthetics, anti-histamines or nicotine, whereby the active agent is used as a pharmacologically acceptable salt and is present in the liquid in at least equimolar amounts with potassium sorbate.
(FR)
L'invention concerne une forme galénique aqueuse liquide pour applications sublinguales ou nasales de principes actifs présentant des groupes amino, telles que par ex. des analgésiques, notamment des opiacées, des anesthésiques locaux, des antihistaminiques ou de la nicotine, pour laquelle le principe actif s'utilise sous forme de sel pharmaceutiquement admissible et se présente dans le liquide avec du sorbat de K, dans une quantité au moins équimolaire.
Also published as
Latest bibliographic data on file with the International Bureau