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1. WO2006099448 - ACCELERATED CD8+ T-CELL MEMORY AFTER DENDRITIC CELL VACCINATION

Publication Number WO/2006/099448
Publication Date 21.09.2006
International Application No. PCT/US2006/009220
International Filing Date 14.03.2006
IPC
C12N 5/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
CPC
A61K 2039/5154
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
515Animal cells
5154Antigen presenting cells [APCs], e.g. dendritic cells, macrophages
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 2039/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
57characterised by the type of response, e.g. Th1, Th2
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Applicants
  • UNIVERSITY OF IOWA RESEARCH FOUNDATION [US]/[US] (AllExceptUS)
  • HARTY, John [US]/[US] (UsOnly)
  • BADOVINAC, Vladimir, P. [US]/[US] (UsOnly)
  • MESSINGHAM, Kelly, A.N. [US]/[US] (UsOnly)
Inventors
  • HARTY, John
  • BADOVINAC, Vladimir, P.
  • MESSINGHAM, Kelly, A.N.
Agents
  • HUIZENGA, David, E.
Priority Data
60/661,35514.03.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ACCELERATED CD8+ T-CELL MEMORY AFTER DENDRITIC CELL VACCINATION
(FR) PRODUCTION ACCELEREE DES LYMPHOCYTES T MEMOIRE CD8+ APRES VACCINATION AVEC LES CELLULES DENDRITIQUES
Abstract
(EN)
Disclosed are compositions and methods for Here, it is shown that vaccination with peptide-coated dendritic cells (DC) generated antigen-(Ag) specific CD8+ T-cells with the phenotype and function of memory T-cells as early as 4-6 days after immunization. These memory-like CD8+ T-cells underwent vigorous secondary expansion, resulting in rapid generation of elevated secondary memory CD8+ T-cell numbers and increased protective immunity, in response to a variety of booster immunizations. However, concurrent inflammation prevented the rapid generation of memory T-cells by DC immunization. Thus, DC vaccination, in the absence of overt inflammation, accelerated memory cell generation and dramatically reduced the interval required for booster amplification of memory CD8+ T-cell numbers.
(FR)
L'invention porte sur des compositions et sur des méthodes, et il s'avère que la vaccination avec des cellules dendritiques (CD) à enrobage peptidique a généré des lymphocytes CD8+ T spécifiques d'un antigène (Ag) ayant le phénotype et la fonction des lymphocytes T mémoire dès 4 à 6 jours après immunisation. Ces lymphocytes T CD8+ analogues à une mémoire ont été soumis à une dilatation secondaire intense, entraînant une génération rapide de nombres élevés de lymphocytes T CD8+ mémoire secondaires et une immunité protectrice renforcée en réaction à diverses immunisations par injection de rappel. Toutefois, une inflammation concomitante à empêcher la génération rapide des lymphocytes T. mémoire pas immunisations avec les cellules dendritiques. En conséquence, la vaccination avec les cellules dendritiques, en l'absence d'une inflammation patente, a accéléré la génération des lymphocytes T mémoire et considérablement réduit l'intervalle requis pour l'amplification par injection de rappel des quantités de lymphocytes T CD8+ mémoire.
Also published as
EP6748383
Latest bibliographic data on file with the International Bureau