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1. (WO2006099165) CRYSTALLINE FORMS OF A BIPHENYL COMPOUND

Pub. No.:    WO/2006/099165    International Application No.:    PCT/US2006/008644
Publication Date: Fri Sep 22 01:59:59 CEST 2006 International Filing Date: Fri Mar 10 00:59:59 CET 2006
IPC: C07D 211/46
A61K 31/45
A61P 11/06
Applicants: THERAVANCE, INC.
AXT, Sabine
CHURCH, Timothy J.
MALATHONG, Viengkham
Inventors: AXT, Sabine
CHURCH, Timothy J.
MALATHONG, Viengkham
Title: CRYSTALLINE FORMS OF A BIPHENYL COMPOUND
Abstract:
The invention provides crystalline forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester, and pharmaceutically acceptable solvates thereof. The crystalline form can be a freebase, or a salt such as a diphosphate, monosulfate or dioxalate salt. The invention also provides pharmaceutical compositions comprising these crystalline compounds or prepared using these compounds; processes and intermediates for preparing the crystalline compounds; and methods of using these compounds to treat a pulmonary disorder.