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1. WO2006099005 - METHOD FOR IDENTIFYING AGENTS WHICH MODULATE GTPASE ACTIVITY INVOLVED IN INSULIN-STIMULATED GLUT4 TRANSLOCATION

Publication Number WO/2006/099005
Publication Date 21.09.2006
International Application No. PCT/US2006/008336
International Filing Date 08.03.2006
IPC
C12Q 1/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
CPC
C12Q 1/48
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
48involving transferase
G01N 33/566
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
566using specific carrier or receptor proteins as ligand binding reagents ; where possible specific carrier or receptor proteins are classified with their target compounds
Applicants
  • TRUSTEES OF DARTMOUTH COLLEGE [US]/[US] (AllExceptUS)
  • LIENHARD, Gustav, E. [US]/[US] (UsOnly)
  • KANE, Susan [GB]/[US] (UsOnly)
  • MIINEA, Christinel, P. [RO]/[US] (UsOnly)
  • SANO, Hiroyuki [JP]/[US] (UsOnly)
Inventors
  • LIENHARD, Gustav, E.
  • KANE, Susan
  • MIINEA, Christinel, P.
  • SANO, Hiroyuki
Agents
  • LICATA, Jane, Massey
Priority Data
60/660,13109.03.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR IDENTIFYING AGENTS WHICH MODULATE GTPASE ACTIVITY INVOLVED IN INSULIN-STIMULATED GLUT4 TRANSLOCATION
(FR) PROCEDE D’IDENTIFICATION D’AGENTS MODULANT L’ACTIVITE GTPASE IMPLIQUEE DANS LA TRANSLOCATION DE GLUT4 STIMULEE PAR L’INSULINE
Abstract
(EN)
The present invention is a method for identifying agents that modulate the GTPase activity of AS160. In the instant assay, AS160 or the GAP domain thereof is contacted with a test agent, in the presence of GTP-bound Rab (2A, 8A, 8B, 10, or 14), and the AS160 GAP domain-mediated hydrolysis of GTP to GDP is monitored.
(FR)
La présente invention concerne un procédé destiné à identifier des agents qui modulent l’activité GTPase de l’AS160. Dans un échantillon instantané, l’AS160 ou le domaine GAP de celui-ci entre en contact avec un agent de test, en présence de Rab liée à GTP (2A, 8A, 8B, 10, ou 14), et l’hydrolyse de GTP en GDP médiée par le domaine GAP de l’AS160 est surveillée.
Also published as
EP6737503
Latest bibliographic data on file with the International Bureau