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1. WO2006098961 - FUSED THIENO [2, 3-B] PYRIDINE AND THIAZOLO [5, 4-B] PYRIDINE COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY

Publication Number WO/2006/098961
Publication Date 21.09.2006
International Application No. PCT/US2006/008145
International Filing Date 07.03.2006
IPC
C07D 495/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 495/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
12in which the condensed system contains three hetero rings
14Ortho-condensed systems
C07D 495/20 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
12in which the condensed system contains three hetero rings
20Spiro-condensed systems
C07D 513/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/4365 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4365the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
A61K 31/4545 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
4545containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
Applicants
  • SCHERING CORPORATION [US]/[US] (AllExceptUS)
  • TAGAT, Jayaram, R. [US]/[US] (UsOnly)
  • GUZI, Timothy. J. [US]/[US] (UsOnly)
  • LABROLI, Marc [US]/[US] (UsOnly)
  • POKER, Cory [US]/[US] (UsOnly)
  • XIAO, Yushi [CN]/[US] (UsOnly)
  • KEREKES, Angela, D. [US]/[US] (UsOnly)
  • YU, Tao [CN]/[US] (UsOnly)
  • PALIWAL, Sunil [IN]/[US] (UsOnly)
  • TSUI, Hon-Chung [CN]/[US] (UsOnly)
  • SHIH, Neng-Yang [US]/[US] (UsOnly)
  • MCCOMBIE, Stuart, W. [US]/[US] (UsOnly)
  • MADISON, Vincent, S. [US]/[US] (UsOnly)
  • LESBURG, Charles, A. [US]/[US] (UsOnly)
  • DUCA, Jose, S. [AR]/[US] (UsOnly)
Inventors
  • TAGAT, Jayaram, R.
  • GUZI, Timothy. J.
  • LABROLI, Marc
  • POKER, Cory
  • XIAO, Yushi
  • KEREKES, Angela, D.
  • YU, Tao
  • PALIWAL, Sunil
  • TSUI, Hon-Chung
  • SHIH, Neng-Yang
  • MCCOMBIE, Stuart, W.
  • MADISON, Vincent, S.
  • LESBURG, Charles, A.
  • DUCA, Jose, S.
Agents
  • BANERJEE, Krishna, G.
Priority Data
60/659,88809.03.2005US
60/712,27429.08.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FUSED THIENO [2, 3-B] PYRIDINE AND THIAZOLO [5, 4-B] PYRIDINE COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY
(FR) COMPOSES SERVANT A INHIBER L'ACTIVITE DE LA KINESINE KSP
Abstract
(EN)
The present invention provides compounds of Formula (I) (wherein R1, R3, X, W, Z and ring Y are as defined herein). The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.
(FR)
L'invention concerne des composés de formule (I) (dans laquelle R1, R3, X, W, Z et le cycle Y sont tels que définis dans la description). Cette invention concerne également des compositions comprenant ces composés, et servant à traiter des maladies liées à une prolifération cellulaire, ou des troubles qui sont associés à l'activité de la kinésine KSP, ainsi qu'à inhiber l'activité de cette kinésine KSP.
Latest bibliographic data on file with the International Bureau