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1. WO2006098852 - HYDROXYALKYL SUBSTITUTED IMIDAZOQUINOLINES

Publication Number WO/2006/098852
Publication Date 21.09.2006
International Application No. PCT/US2006/006223
International Filing Date 22.02.2006
IPC
C07D 471/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12in which the condensed system contains three hetero rings
14Ortho-condensed systems
A61K 31/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
CPC
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • COLEY PHARMACEUTICAL GROUP, INC. [US]/[US] (AllExceptUS)
  • KSHIRSAGAR, Tushar A., [IN]/[US] (UsOnly)
  • MERRILL, Bryon A., [US]/[US] (UsOnly)
  • LANGER, Scott E., [US]/[US] (UsOnly)
  • LINDSTROM, Kyle J., [US]/[US] (UsOnly)
  • JOHANNESSEN, Sarah C., [US]/[US] (UsOnly)
  • MARSZALEK, Gregory J., [US]/[US] (UsOnly)
  • MANSKE, Karl J., [US]/[US] (UsOnly)
  • HEPPNER, Philip D., [US]/[US] (UsOnly)
  • LUNDQUIST, Gregory D. Jr., [US]/[US] (UsOnly)
Inventors
  • KSHIRSAGAR, Tushar A.,
  • MERRILL, Bryon A.,
  • LANGER, Scott E.,
  • LINDSTROM, Kyle J.,
  • JOHANNESSEN, Sarah C.,
  • MARSZALEK, Gregory J.,
  • MANSKE, Karl J.,
  • HEPPNER, Philip D.,
  • LUNDQUIST, Gregory D. Jr.,
Agents
  • GATES, Edward, R.
Priority Data
60/655,38023.02.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HYDROXYALKYL SUBSTITUTED IMIDAZOQUINOLINES
(FR) IMIDAZOQUINOLINES A SUBSTITUTION HYDROXYALKYLE
Abstract
(EN)
Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-&agr; biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
(FR)
La présente invention concerne certains imidazoquinolines portant un substituant hydroxyméthyle ou hydroxyéthyle en position 2, des compositions pharmaceutiques contenant ces composés, des intermédiaires, des procédés de fabrication et d'utilisation de ces composés en tant qu'immunomodulateurs, de préférence pour induire une biosynthèse d'IFN-a chez des animaux, et pour le traitement d'affections, y-compris virales et néoplasiques.
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