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1. WO2006098744 - IFBM’S TO PROMOTE ATTACHMENT OF TARGET ANALYTES

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

WHAT IS CLAIMED:

1. An IFBM comprising:
a. at least one implant module; and
b. at least one analyte module;
wherein said implant module comprises a peptide that comprises the sequence set forth in any of SEQ ID NOs: 1-8, 39-43, 95-96, or 97-558.

2. The IFBM of claim 1, wherein said implant module binds to an implant made from a material selected from the group consisting of:
a. a polymer;
b. a ceramic;
c. a plastic; and
d. a metal.

3. The IFBM of claim 2, wherein said implant module binds to an implant made from a polymer which is polylactic acid.

4. The IFBM of claim 2, wherein said implant module binds to an implant made from polymer which is collagen.

5. The IFBM of claim 2, wherein said implant module binds to an implant made from a plastic which is polytetrofluoroethylene.

6. The IFBM of claim 2, wherein said implant module binds to an implant made from a metal which is titanium alloy.

7. The IFBM of claim 2, wherein said implant module binds to an implant made from a ceramic material which is zirconium oxide.

8. The IFBM of claim 1, wherein said analyte module binds to a protein selected from the group consisting of:
a. a Bone Morphogenic Protein;
b. Vascular Endothelial Growth Factor;
c. Platelet-derived Growth Factor;
d. Transforming Growth Factor-/3;
e . Insulin Growth Factor- 1 ;
f. Insulin Growth Factor-2;
g. Fibroblast Growth Factor;
h. Nerve Growth Factor; and
i. Placental Growth Factor.

9. The IFBM of claim 1, wherein said analyte module binds to Bone Morphogenic Protein-2.

10. The IFBM of claim 1, wherein said analyte module binds to a cell.

11. The IFBM of claim 10, wherein said analyte module binds to an osteoblast.

12. The IFBM of claim I, wherein said analyte module comprises a peptide comprising the sequence set forth in any of SEQ ID NOs: 11-28, 44-74, or 77-94.

13. The IFBM of claim I, wherein said analyte module comprises a peptide that comprises the sequence RGD.

14. The IFBM of claim 1, wherein said analyte module comprises a peptide that comprises the sequence YIGSR.

15. The IFBM of claim 12, wherein said analyte module comprises a peptide that comprises the sequence IKVAV.

16. The IFBM of claim 1, wherein said implant module is linked to at least two analyte modules.

17. The IFBM of claim 16, wherein said analyte modules comprise at least one analyte module that binds a growth factor and at least one analyte module that binds a cell.

18. An implant coated with at least two IFBMs of claim 1, wherein at least two of said at least two IFBMs are different from each other.

19. The IFBM of claim 1 , wherein said analyte module binds to each of BMPRI and BMPRII and has BMP activity.