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1. WO2006098415 - DRUG CARRIER

Publication Number WO/2006/098415
Publication Date 21.09.2006
International Application No. PCT/JP2006/305304
International Filing Date 10.03.2006
IPC
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 47/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
CPC
A61K 47/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
A61K 47/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 47/6415
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
6415Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
Applicants
  • 株式会社オキシジェニクス OXYGENIX CO., LTD. [JP]/[JP] (AllExceptUS)
  • 学校法人早稲田大学 WASEDA UNIVERSITY [JP]/[JP] (AllExceptUS)
  • 武岡 真司 TAKEOKA, Shinji [JP]/[JP] (UsOnly)
  • 岡村 陽介 OKAMURA, Yosuke [JP]/[JP] (UsOnly)
  • 金澤 秀雄 KANAZAWA, Hideo [JP]/[JP] (UsOnly)
  • 久本 秀治 HISAMOTO, Shuji [JP]/[JP] (UsOnly)
  • 久保田 恒平 KUBOTA, Kohei [JP]/[JP] (UsOnly)
  • 小幡 洋輔 OBATA, Yosuke [JP]/[JP] (UsOnly)
Inventors
  • 武岡 真司 TAKEOKA, Shinji
  • 岡村 陽介 OKAMURA, Yosuke
  • 金澤 秀雄 KANAZAWA, Hideo
  • 久本 秀治 HISAMOTO, Shuji
  • 久保田 恒平 KUBOTA, Kohei
  • 小幡 洋輔 OBATA, Yosuke
Agents
  • 小林 浩 KOBAYASHI, Hiroshi
Priority Data
2005-07566316.03.2005JP
2005-25236631.08.2005JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) DRUG CARRIER
(FR) VECTEUR DE MEDICAMENT
(JA) 薬物運搬体
Abstract
(EN)
An object of the invention is to provide a dug carrier that is capable of regulating pharmacokinetics in vivo. The invention is directed to the drug carrier comprising a molecular assembly by which a dug is supported and the object can be achieved by releasing part of amphiphilic molecules constituting the molecular assembly from the molecular assembly due to external environmental change. A phenomenon in which the amphiphilic molecule is released from the molecular assembly because a hydrophilic-hydrophobic balance is shifted to hydrophilicity by external environmental change is utilized in the invention.
(FR)
L’un des objectifs de l’invention est de fournir un vecteur de médicament pouvant réguler la pharmacocinétique in vivo. L’invention concerne un vecteur de médicament comprenant un assemblage moléculaire servant de vecteur à un médicament et l’objectif peut être atteint en détachant une partie des molécules amphiphiles constituant l’assemblage moléculaire du reste de l’assemblage moléculaire sous l’effet de modifications de l’environnement extérieur. L’invention exploite une particularité des molécules amphiphiles de se détacher de l’assemblage moléculaire à la suite d’un basculement de l’équilibre hydrophiles-hydrophobes vers l’hydrophilicité sous l’effet de modifications de l’environnement extérieur.
(JA)
本発明は、生体内における薬物動態を制御することのできる薬物運搬体を提供することを課題とする。本発明は、薬物が担持されている分子集合体を含む薬物運搬体であって、その分子集合体を構成する一部の両親媒性分子が外部環境の変化によって分子集合体から遊離することによって、上記課題を解決することができる。本発明においては、両親媒性分子が外部環境の変化によって親水性−疎水性バランスが親水性に傾くために分子集合体から遊離する現象を利用する。
Also published as
EP6729294
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