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1. WO2006096828 - CHIMERIC PROTEINS WITH PHOSPHATIDYLSERINE BINDING DOMAINS

Publication Number WO/2006/096828
Publication Date 14.09.2006
International Application No. PCT/US2006/008541
International Filing Date 09.03.2006
Chapter 2 Demand Filed 09.03.2006
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 1/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
CPC
A01K 2267/0375
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
035Animal model for multifactorial diseases
0375Animal model for cardiovascular diseases
A01K 67/027
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 7/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
04Antihaemorrhagics; Procoagulants; Haemostatatic agents; Antifibrinolytic agents
C07K 14/4721
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4721Lipocortins
C07K 14/70596
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70596Molecules with a "CD"-designation not provided for elsewhere
Applicants
  • LIND, Stuart, E. [US]/[US]
  • DING, Wei-Qun [US]/[US]
  • HARRISON, Roger, G., Jr. [US]/[US]
Inventors
  • LIND, Stuart, E.
  • DING, Wei-Qun
  • HARRISON, Roger, G., Jr.
Agents
  • CORBET, Christopher, W.
Priority Data
60/659,93809.03.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CHIMERIC PROTEINS WITH PHOSPHATIDYLSERINE BINDING DOMAINS
(FR) PROTEINES CHIMERIQUES POSSEDANT DES DOMAINES DE LIAISON A PHOSPHATIDYLSERINE
Abstract
(EN)
Chimeric proteins comprising soluble Tissue Factor (sTF) and another subunit (e.g., annexin V) are described. The proteins promote blood clotting and/or inhibit cancer by targeting sTF to specific receptors such as phosphatidyl serine (PS) on activated cells. These chimeric proteins are useful in treating patients with excessive bleeding due to inborn problems, drug therapy, trauma or surgery and/or as an anti-cancer therapy, for example by causing blood vessels feeding cancers to become clotted, thereby preventing adequate flow of blood to a tumor, which in turn will lead to tumor inhibition and death or may be used in a therapy to cause clotting within blood vessels that pose a threat in the subject in non-cancerous conditions.
(FR)
L'invention porte sur des protéines chimériques contenant un facteur de tissu soluble (sTF) et une autre sous-unité (par exemple annexine V). ces protéines favorisent la coagulation sanguine et/ou inhibent le cancer par ciblage de sTF avec des récepteurs spécifiques tels que phosphatidylsérine (PS) sur des cellules activées. Ces protéines chimériques sont utiles dans le traitement de patients souffrant de saignements excessifs en raison de problèmes congénitaux, de soins par médicaments, de traumatismes ou d'une opérations chirurgicale, et/ou dans une thérapie anticancéreuse, en provoquant par exemple la coagulation de vaisseaux sanguins alimentant les cancers, empêchant ainsi le flux approprié de sang vers une tumeur, ce qui provoquera ainsi l'inhibition ou la mort de la tumeur. Ces protéines peuvent aussi être utilisées pour provoquer la coagulation de vaisseaux sanguins qui représentent une menace à un sujet dans des conditions non cancéreuses.
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