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1. WO2006096780 - SIRTUIN RELATED THERAPEUTICS AND DIAGNOSTICS FOR NEURODEGENERATIVE DISEASES

Publication Number WO/2006/096780
Publication Date 14.09.2006
International Application No. PCT/US2006/008290
International Filing Date 07.03.2006
IPC
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/122 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
122having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 31/015 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
01Hydrocarbons
015carbocyclic
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
CPC
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/015
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
01Hydrocarbons
015carbocyclic
A61K 31/122
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
122having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
Applicants
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]/[US] (AllExceptUS)
  • BIOMOL INTERNATIONAL L.P. [US]/[US] (AllExceptUS)
  • SINCLAIR, David [AU]/[US] (UsOnly)
  • BITTERMAN, Kevin, J. [US]/[US] (UsOnly)
  • TSAI, Li-huei [US]/[US] (UsOnly)
  • NGUYEN, Minh [CA]/[CA] (UsOnly)
  • HOWITZ, Konrad [US]/[US] (UsOnly)
  • ZIPKIN, Robert [US]/[US] (UsOnly)
Inventors
  • SINCLAIR, David
  • BITTERMAN, Kevin, J.
  • TSAI, Li-huei
  • NGUYEN, Minh
  • HOWITZ, Konrad
  • ZIPKIN, Robert
Agents
  • STERN-DOMBAL, Charlene
Priority Data
11/074,37407.03.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SIRTUIN RELATED THERAPEUTICS AND DIAGNOSTICS FOR NEURODEGENERATIVE DISEASES
(FR) PRODUITS DE TRAITEMENT ET DE DIAGNOSTIC ASSOCIES A LA SIRTUINE POUR MALADIES NEURODEGENERATIVES
Abstract
(EN)
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine. Also disclosed herein are methods for treating, preventing or diagnosing a disease associated with neuronal cell death, e.g., a neurodegenerative disease.
(FR)
L'invention concerne des méthodes et des compositions permettant de moduler l'activité de protéines membres de la famille des désacétylases sirtuines, l'activité de la protéine p53, l'apoptose, la durée de vie et la sensibilité au stress des cellules et des organismes. Ces méthodes peuvent consister par exemple à faire entrer en contact une cellule avec un composé d'activation tel qu'une flavone, un stilbène, une flavanone, une isoflavone, une catéchine, un chalcone, un tanin, ou une anthocyanidine, ou un composé inhibiteur tel qu'un sphingolipide, p. ex. la sphignosine. L'invention concerne en outre des méthodes permettant le traitement, la prévention ou le diagnostic d'une maladie liée à la mort des cellules neuronales, telle qu'une maladie neurodégénérative.
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