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1. WO2006096652 - PROCESS FOR PREPARING MACROCYCLIC COMPOUNDS

Publication Number WO/2006/096652
Publication Date 14.09.2006
International Application No. PCT/US2006/007954
International Filing Date 06.03.2006
IPC
C07K 5/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
C07D 417/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 401/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
CPC
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
C07D 401/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 417/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07K 5/0808
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
0802with the first amino acid being neutral
0804and aliphatic
0808the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
Applicants
  • BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE]/[DE] (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW)
  • BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE)
  • BUSACCA, Carl, Alan [US]/[US] (UsOnly)
  • GALLOU, Fabrice [FR]/[US] (UsOnly)
  • HADDAD, Nizar [IL]/[US] (UsOnly)
  • HOSSAIN, Azad [BD]/[US] (UsOnly)
  • KAPADIA, Suresh, R. [US]/[US] (UsOnly)
  • LIU, Jianxiu [CN]/[US] (UsOnly)
  • SENANAYAKE, Chris, Hugh [US]/[US] (UsOnly)
  • WEI, Xudong [CN]/[US] (UsOnly)
  • YEE, Nathan, K. [US]/[US] (UsOnly)
Inventors
  • BUSACCA, Carl, Alan
  • GALLOU, Fabrice
  • HADDAD, Nizar
  • HOSSAIN, Azad
  • KAPADIA, Suresh, R.
  • LIU, Jianxiu
  • SENANAYAKE, Chris, Hugh
  • WEI, Xudong
  • YEE, Nathan, K.
Agents
  • MORRIS, Michael, P.
Priority Data
60/659,69608.03.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PREPARING MACROCYCLIC COMPOUNDS
(FR) PREPARATION DE COMPOSES MACROCYCLIQUES
Abstract
(EN)
Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
(FR)
L'invention concerne un procédé de fabrication d'un composé macrocyclique représenté par la formule (I), dans lequel on fait réagir un composé macrocyclique substitué hyddroxyle de formule (3) avec un composé substitué sulfonyle de formule QUIN. Les composés de formule (I) sont des principes actifs puissants pour le traitement de l'infection par le virus de l'hépatite C (VHC).
Other related publications
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