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1. WO2006096624 - PROCESS FOR THE PURIFICATION OF SUBSTITUTED BENZOXAZOLE COMPOUNDS

Publication Number WO/2006/096624
Publication Date 14.09.2006
International Application No. PCT/US2006/007887
International Filing Date 06.03.2006
IPC
C07D 263/56 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52condensed with carbocyclic rings or ring systems
54Benzoxazoles; Hydrogenated benzoxazoles
56with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
CPC
C07D 263/42
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02not condensed with other rings
30having two or three double bonds between ring members or between ring members and non-ring members
34with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36One oxygen atom
42attached in position 5
C07D 263/57
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52condensed with carbocyclic rings or ring systems
54Benzoxazoles; Hydrogenated benzoxazoles
56with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
57Aryl or substituted aryl radicals
Applicants
  • WYETH [US]/[US] (AllExceptUS)
  • IERA, Silvio [CA]/[CA] (UsOnly)
Inventors
  • IERA, Silvio
Agents
  • DELUCA, Mark
Priority Data
60/659,21207.03.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PURIFICATION OF SUBSTITUTED BENZOXAZOLE COMPOUNDS
(FR) PROCEDE DE PURIFICATION DE COMPOSES DU BENZOXAZOLE SUBSTITUE
Abstract
(EN)
The present invention provides processes for the purification of substituted benzoxazole compounds of formla (I), and in particular 2-(3-fluoro-4-hydroxy-phenyl)-7-vinyl- benzooxazol-5-ol. The processes include recrystallizing the compound from a solution comprising acetone and acetonitrile; treating the crude purified product with a clarifying agent in a solution comprising ethyl acetate, and precipitating or triturating the compound from a mixed solvent system.
(FR)
L’invention concerne des procédés de purification de composés du benzoxazole substitué de formule (I), et en particulier du 2-(3-fluoro-4-hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol. Ces procédés comprennent la recristallisation du composé à partir d’une solution contenant de l’acétone et de l’acétonitrile ; le traitement du produit purifié brut par un agent clarifiant dans une solution contenant de l’acétate d’éthyle ; et la précipitation ou la trituration du composé à partir d’un système de solvant mixte.
Also published as
CO07090810
CRCR2007-009326
NO20074103
NZ560547
PH12007501933
RU2007130408
Latest bibliographic data on file with the International Bureau