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1. WO2006096580 - SOLVENT SYSTEM FOR ENHANCING THE SOLUBILITY OF PHARMACEUTICAL AGENTS

Publication Number WO/2006/096580
Publication Date 14.09.2006
International Application No. PCT/US2006/007788
International Filing Date 06.03.2006
Chapter 2 Demand Filed 08.01.2007
IPC
A61K 9/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
CPC
A61K 31/192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-arylpropionic acids, ethacrynic acid
A61K 31/765
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
74Synthetic polymeric materials
765Polymers containing oxygen
A61K 47/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
12Carboxylic acids; Salts or anhydrides thereof
A61K 9/0053
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
A61K 9/4825
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4816Wall or shell material
4825Proteins, e.g. gelatin
A61K 9/4833
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4833Encapsulating processes; Filling of capsules
Applicants
  • BANNER PHARMACAPS, INC. [US]/[US] (AllExceptUS)
  • CHIDAMBARAM, Nachiappan [IN]/[US] (UsOnly)
  • FATMI, Aqeel [US]/[US] (UsOnly)
Inventors
  • CHIDAMBARAM, Nachiappan
  • FATMI, Aqeel
Agents
  • PABST, Patrea
Priority Data
60/659,67908.03.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SOLVENT SYSTEM FOR ENHANCING THE SOLUBILITY OF PHARMACEUTICAL AGENTS
(FR) SYSTEME DE SOLVANT DESTINE A AMELIORER LA SOLUBILITE DES AGENTS PHARMACEUTIQUES
Abstract
(EN)
Liquid and semi-solid pharmaceutical compositions, which can be administered in liquid form or can be used for preparing capsules, are described herein. The composition comprises the salt of one ore more active agents, polyethylene glycol, 0.2-1.0 mole equivalents of a de-ionizing agent per mole of active agent, and water. The pH of the composition is adjusted within the range of 2.5 - 7.5. The de-ionizing agent causes partial de- ionization (neutralization) of the salt of the active agent resulting in enhanced bioavailability of salts of weakly acidic, basic or amphoteric active agents as well as lesser amounts of polyethylene glycol (PEG) esters.
(FR)
La présente invention concerne des compositions pharmaceutiques liquides et semi-solides, qui peuvent être administrées sous forme liquide ou utilisées pour la préparation de gélules. La composition comprend un sel d’un ou de plusieurs agents actifs, du polyéthylène glycol, 0,2-1,0 équivalent molaire d’un agent de désionisation par mole de principe actif, ainsi que de l’eau. Le pH de la composition est ajusté dans une fourchette comprise entre 2,5 et 7,5. L’agent de désionisation induit une désionisation (neutralisation) partielle du sel du principe actif, avec pour résultat une biodisponibilité accrue des sels des agents actifs amphotères, basiques ou faiblement acides ainsi que de moindres quantités d'esters de polyéthylène glycol (PEG).
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