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1. WO2006095740 - METHOD FOR SYNTHESIZING NUCLEIC ACID BY USING SUBSTITUTED CARBAMOYL GROUP AS PROTECTING GROUP

Publication Number WO/2006/095740
Publication Date 14.09.2006
International Application No. PCT/JP2006/304400
International Filing Date 07.03.2006
Chapter 2 Demand Filed 20.12.2006
IPC
C07H 19/073 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
073with 2-deoxyribosyl as the saccharide radical
C07H 19/173 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
16Purine radicals
173with 2-deoxyribosyl as the saccharide radical
CPC
C07H 19/073
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
06Pyrimidine radicals
073with 2-deoxyribosyl as the saccharide radical
C07H 19/173
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
16Purine radicals
173with 2-deoxyribosyl as the saccharide radical
Y02P 20/55
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
20Technologies relating to chemical industry
50Improvements relating to the production of products other than chlorine, adipic acid, caprolactam, or chlorodifluoromethane, e.g. bulk or fine chemicals or pharmaceuticals
55Synthetic design, e.g. reducing the use of auxiliary or protecting groups
Applicants
  • 国立大学法人 東京工業大学 TOKYO INSTITUTE OF TECHNOLOGY [JP]/[JP] (AllExceptUS)
  • 関根 光雄 SEKINE, Mitsuo [JP]/[JP] (UsOnly)
  • 宮田 健一 MIYATA, Kenichi [JP]/[JP] (UsOnly)
  • 玉虫 隆二 TAMAMUSHI, Ryuji [JP]/[JP] (UsOnly)
  • 清尾 康志 SEIO, Kohji [JP]/[JP] (UsOnly)
Inventors
  • 関根 光雄 SEKINE, Mitsuo
  • 宮田 健一 MIYATA, Kenichi
  • 玉虫 隆二 TAMAMUSHI, Ryuji
  • 清尾 康志 SEIO, Kohji
Agents
  • 野村 健一 NOMURA, Kenichi
Priority Data
2005-06489209.03.2005JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR SYNTHESIZING NUCLEIC ACID BY USING SUBSTITUTED CARBAMOYL GROUP AS PROTECTING GROUP
(FR) PROCEDE DE SYNTHESE D’ACIDE NUCLEIQUE UTILISANT UN GROUPE CARBAMOYLE SUBSTITUE EN TANT QUE GROUPE PROTECTEUR
(JA) 置換カルバモイル基を保護基とした核酸の合成方法
Abstract
(EN)
Disclosed is a method for synthesizing a nucleic acid which is characterized by comprising a step wherein a compound represented by the general formula (III) below is obtained by reacting a compound represented by the general formula (I) below with an isocyanate derivative represented by the general formula (II) below, and another step wherein the compound represented by the general formula (I) below is obtained by heating the compound represented by the general formula (III) below or irradiating it with microwaves. (In the formula (I), X represents a portion other than an amino group in a nucleic acid base or the like that has an amino group.) (In the formula (II), Y represents an electron-withdrawing group.) (In the formula (III), X and Y are as defined above.)
(FR)
L’invention décrit un procédé de synthèse d’un acide nucléique caractérisé en ce qu’il comprend une étape au cours de laquelle on obtient un composé de formule générale (III) ci-dessous en faisant réagir un composé de formule générale (I) ci-dessous avec un dérivé isocyanate de formule générale (II) ci-dessous, et une autre étape au cours de laquelle on obtient un composé de formule générale (I) ci-dessous en chauffant le composé de formule générale (III) ou en l’irradiant par des micro-ondes. NH2-X (I) (Dans la formule (I), X représente un fragment autre qu’un groupe amino dans une base d’acide nucléique ou autre espèce similaire ayant un groupe amino). O=C=N-Y (II) (Dans la formule (II), Y représente un groupe accepteur d’électrons.) [Formule chimique 3] (III) (Dans la formule (III), X et Y sont tels que précédemment définis).
(JA)
 一般式(I): 【化1】 〔式中、Xはアミノ基を持つ核酸塩基などのアミノ基以外の部分を表す。〕 で表される化合物を、一般式(II): 【化2】 〔式中、Yは電子吸引性基を表す。〕 で表されるイソシアナート誘導体と反応させ、一般式(III): 【化3】 〔式中、X及びYは前記と同意義を示す。〕 で表される化合物を得る工程、及び一般式(III)で表される化合物を、加熱又はマイクロウェーブ照射し、一般式(I)で表される化合物を得る工程を含むことを特徴とする核酸の合成方法を提供する。
Also published as
EP6728719
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