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1. WO2006095359 - SYNTHESIS OF 2-DEOXY-2, 2-DI FLUORO-D-RIBO FURANOSE-3, 5 DI(4-METHY/4-NITRO-CHLORO)BENZOATE AND ITS CONVERSION TO GEMCITABINE HYDROCHLORIDE THEREOF

Publication Number WO/2006/095359
Publication Date 14.09.2006
International Application No. PCT/IN2005/000160
International Filing Date 19.05.2005
IPC
C07H 19/073 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
073with 2-deoxyribosyl as the saccharide radical
CPC
C07H 19/073
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
06Pyrimidine radicals
073with 2-deoxyribosyl as the saccharide radical
Applicants
  • SMS PHARMACEUTICALS LIMITED [IN]/[IN] (AllExceptUS)
  • POTLURI, Ramesh, Babu [IN]/[IN] (UsOnly)
  • VENKATA SUBRAMANIAN, Hariharakrishnan [IN]/[IN] (UsOnly)
  • BETINI, Ramesh [IN]/[IN] (UsOnly)
  • GUNTURU, Satyanarayana [IN]/[IN] (UsOnly)
Inventors
  • POTLURI, Ramesh, Babu
  • VENKATA SUBRAMANIAN, Hariharakrishnan
  • BETINI, Ramesh
  • GUNTURU, Satyanarayana
Agents
  • VISHWANATH, Ramesh, B.
Priority Data
240/CHE/200510.03.2005IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYNTHESIS OF 2-DEOXY-2, 2-DI FLUORO-D-RIBO FURANOSE-3, 5 DI(4-METHY/4-NITRO-CHLORO)BENZOATE AND ITS CONVERSION TO GEMCITABINE HYDROCHLORIDE THEREOF
(FR) SYNTHESE DU 2-DESOXY-2,2-DIFLUORO-D-RIBOFURANOSE-3,5-DI(4-METHYL-4-NITRO-CHLORO)BENZOATE ET SA CONVERSION EN CHLORHYDRATE DE GEMCITABINE
Abstract
(EN)
The invention describes the synthesis of hereto unreported 2-deoxy-2,2-difluoro-D-ribofuranose-3,5-di-(aroyl) derivative of formula-Vb, where in R=;CH3,CI,NO2 and its conversion to Gemcitabine HCl of formula-I, an anti cancer product.
(FR)
L'invention décrit la synthèse d’un dérivé non rapporté jusqu’ici, le 2-désoxy-2,2-difluoro-D-ribofuranose-3,5-di-(aroyle) répondant à la formule (Vb), où R représente CH3, Cl ou NO2. L’invention décrit également sa conversion en chlorhydrate de Gemcitabine de formule (I), un produit anti-cancéreux.
Also published as
EP5750180
Latest bibliographic data on file with the International Bureau