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1. WO2006094840 - COMPOUNDS

Publication Number WO/2006/094840
Publication Date 14.09.2006
International Application No. PCT/EP2006/002480
International Filing Date 09.03.2006
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
16
acylated on ring nitrogen atoms
18
by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
C07D 295/18 (2006.01)
A61P 25/00 (2006.01)
A61K 31/495 (2006.01)
CPC
C07D 295/192
Applicants
  • GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
  • BRADLEY, Daniel, Marcus [GB/GB]; GB (UsOnly)
  • BRANCH, Clive, Leslie [GB/GB]; GB (UsOnly)
  • BROWN, Bethany, Joy [GB/GB]; GB (UsOnly)
  • CHAN, Wai, Ngor [GB/GB]; GB (UsOnly)
  • COULTON, Steven [GB/GB]; GB (UsOnly)
  • DEAN, Anthony, William [GB/GB]; GB (UsOnly)
  • DOYLE, Paul, Martin [GB/GB]; GB (UsOnly)
  • EVANS, Brian [GB/GB]; GB (UsOnly)
  • GILPIN, Martin, Leonard [GB/GB]; GB (UsOnly)
  • GOUGH, Sharon, Lisa [GB/GB]; GB (UsOnly)
  • MACRITCHIE, Jacqueline, Anne [GB/GB]; GB (UsOnly)
  • MARSHALL, Howard, Robert [GB/GB]; GB (UsOnly)
  • NASH, David, John [GB/GB]; GB (UsOnly)
  • PORTER, Roderick, Alan [GB/GB]; GB (UsOnly)
  • STASI, Luigi, Piero [IT/IT]; IT (UsOnly)
Inventors
  • BRADLEY, Daniel, Marcus; GB
  • BRANCH, Clive, Leslie; GB
  • BROWN, Bethany, Joy; GB
  • CHAN, Wai, Ngor; GB
  • COULTON, Steven; GB
  • DEAN, Anthony, William; GB
  • DOYLE, Paul, Martin; GB
  • EVANS, Brian; GB
  • GILPIN, Martin, Leonard; GB
  • GOUGH, Sharon, Lisa; GB
  • MACRITCHIE, Jacqueline, Anne; GB
  • MARSHALL, Howard, Robert; GB
  • NASH, David, John; GB
  • PORTER, Roderick, Alan; GB
  • STASI, Luigi, Piero; IT
Agents
  • CONNELL, Anthony, Christopher; GlaxoSmithKline Corporate Intellectual Property 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data
0505085.111.03.2005GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUNDS
(FR) COMPOSÉS
Abstract
(EN)
The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
(FR)
L’invention concerne un composé de la formule (I) ou un sel ou un solvate de celui-ci : où R1, n, X, Y et Z sont tels que définis dans la description, et les utilisations de tels composés. Les composés inhibent les transporteurs de GlyT1 et sont utiles dans le traitement de certains troubles neurologiques et neuropsychiatriques, y compris la schizophrénie.
Also published as
Latest bibliographic data on file with the International Bureau