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1. WO2006094688 - ORGANIC COMPOUNDS

Publication Number WO/2006/094688
Publication Date 14.09.2006
International Application No. PCT/EP2006/001866
International Filing Date 01.03.2006
IPC
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
G01N 33/542 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
536with immune complex formed in liquid phase
542with steric inhibition or signal modification, e.g. fluorescent quenching
CPC
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
G01N 2500/02
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
G01N 33/5308
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
5308for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
G01N 33/542
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
536with immune complex formed in liquid phase
542with steric inhibition or signal modification, e.g. fluorescent quenching
Applicants
  • NOVARTIS AG [CH]/[CH] (AE, AG, AL, AM, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW)
  • NOVARTIS PHARMA GMBH [AT]/[AT] (AT)
  • AUER, Manfred [AT]/[AT] (UsOnly)
  • MEISNER, Nicole-Claudia [AT]/[AT] (UsOnly)
  • HINTERSTEINER, Martin [AT]/[AT] (UsOnly)
  • SCHINDLER, Torsten [DE]/[AT] (UsOnly)
  • GSTACH, Hubert [AT]/[AT] (UsOnly)
Inventors
  • AUER, Manfred
  • MEISNER, Nicole-Claudia
  • HINTERSTEINER, Martin
  • SCHINDLER, Torsten
  • GSTACH, Hubert
Agents
  • ROTH, Peter, R.
Priority Data
0504428.403.03.2005GB
0504430.003.03.2005GB
0504431.803.03.2005GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ORGANIC COMPOUNDS
(FR) COMPOSES ORGANIQUES
Abstract
(EN)
The invention relates to an assay for identifying an agent that modulates the interaction of a mRNA with a target protein, e.g. HuR and to organic compounds of formula (I); wherein R1, R2 and R3 are as defined above, and their use, e.g. as an inhibitor on the complex-formation of an ARE-containing mRNA and a target protein.
(FR)
Cette invention concerne un dosage destiné à identifier un agent qui module l'interaction d'un ARNm et d'une protéine cible, telle que HuR. Elle concerne des composés organiques de la formule (I), dans laquelle R1, R2 et R3 sont tels que définis dans le mémorandum descriptif, et l'utilisation desdits composés organiques comme inhibiteurs de la formation en complexe d'un ARNm contenant ARE et d'une protéine cible.
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