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1. WO2006094673 - SYNERGISTIC MIXTURES OF C6- TO C12-ALKANEDI0LS AND TROPOLONE (DERIVATIVES)

Publication Number WO/2006/094673
Publication Date 14.09.2006
International Application No. PCT/EP2006/001800
International Filing Date 27.02.2006
IPC
C12N 15/12 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12N 15/62 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
C12N 5/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C12N 1/15 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
14Fungi ; Culture media therefor
15modified by introduction of foreign genetic material
A01K 67/027 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
CPC
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Applicants
  • LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN [DE]/[DE] (AllExceptUS)
  • ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG [DE]/[DE] (AllExceptUS)
  • LICHTENTHALER, Stefan [DE]/[DE] (UsOnly)
  • HAASS, Christian [DE]/[DE] (UsOnly)
  • NEUMANN, Stefanie [DE]/[DE] (UsOnly)
  • SCHÖBEL, Susanne [DE]/[DE] (UsOnly)
  • HERTWECK, Maren [DE]/[DE] (UsOnly)
  • BAUMEISTER, Ralf [DE]/[DE] (UsOnly)
Inventors
  • LICHTENTHALER, Stefan
  • HAASS, Christian
  • NEUMANN, Stefanie
  • SCHÖBEL, Susanne
  • HERTWECK, Maren
  • BAUMEISTER, Ralf
Agents
  • VOSSIUS & PARTNER
Priority Data
05005038.408.03.2005EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYNERGISTIC MIXTURES OF C6- TO C12-ALKANEDI0LS AND TROPOLONE (DERIVATIVES)
(FR) NEXINES DE TRI DANS UNE INTERVENTION MEDICALE DE TROUBLES NEUROLOGIQUES ET/OU METABOLIQUES
Abstract
(EN)
The present invention relates to a polynucleotide encoding a specific novel sorting nexin, SNX-B8/30 and is also related to a polypeptide encoded by said polynucleotides. The invention also relates to specific medical, pharmaceutical and scientific uses of said new member of a herein described sorting nexin (SNX) subgroup consisting of SNX-9, SNX- 18 and the herein described SNX-B8/30. Also provided are specific screening methods for agonists or antagonists influencing the function and/or expression of the SNX-B 8/30 and/or the further members of the herein identified subfamily of sorting nexins. Accordingly, the present invention also relates to novel pharmaceutical compositions. These pharmaceutical compositions may, inter alia, be employed in the treatment of diseases/disorders related to (pathological) APP metabolism and/or the insulin metabolism, like Alzheimer's disease or diabetes. Also provided are non-human transgenic animals comprising a modified and/or altered SNX-B8/30 or expressing a heterologous SNX-B8/30.
(FR)
La présente invention a trait à un polynucléotide codant pour une nouvelle nexine de tri spécifique, la SNX-B8/30 ainsi qu'à un polypeptide codé par lesdits polynucléotides. L'invention a également trait à des utilisations spécifiques médicales, pharmaceutiques et scientifiques dudit nouveau membre d'un sous-groupe de nexines de tri (SNX) constitué de SNX-9, SNX-18 et de la SNX-B8/30 de l'invention. L'invention a trait en outre à des procédés de criblage spécifique pour des agonistes et des antagonistes exerçant une influence sur la fonction et/ou l'expression de la SNX-B8/30 et/ou d'autres membres de la sous-familles identifiée de l'invention de nexines de tri. Par conséquent, la présente invention a également trait à de nouvelles compositions pharmaceutiques. Ces compositions pharmaceutiques peuvent, entre autres, être utilisées dans le traitement de maladies/troubles liés au métabolisme de l'APP (pathologique) et/ou le métabolisme de l'insuline, tels que la maladie d'Alzheimer ou le diabète. L'invention a trait enfin à des animaux transgéniques non humains comportant une SNX-B8/30 modifiée et/ou altérée ou exprimant une SNX-B8/30 hétérologue.
Also published as
EP6723132
Latest bibliographic data on file with the International Bureau