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1. WO2006094600 - SUBSTITUTED TETRAHYDROPYRROLOQUINOLINE DERIVATIVES AS KINASE MODULATORS, ESPECIALLY TYROSINE KINASE AND RAF KINASE MODULATORS

Publication Number WO/2006/094600
Publication Date 14.09.2006
International Application No. PCT/EP2006/001281
International Filing Date 13.02.2006
IPC
C07D 471/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
06Peri-condensed systems
A61K 31/437 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
A61P 37/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 17/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
Applicants
  • MERCK PATENT GMBH [DE]/[DE] (AllExceptUS)
  • STAEHLE, Wolfgang [DE]/[DE] (UsOnly)
  • HEINRICH, Timo [DE]/[DE] (UsOnly)
  • KORDOWICZ, Maria [PL]/[DE] (UsOnly)
  • BLAUKAT, Andree [DE]/[DE] (UsOnly)
  • BURGDORF, Lars, Thore [DE]/[DE] (UsOnly)
Inventors
  • STAEHLE, Wolfgang
  • HEINRICH, Timo
  • KORDOWICZ, Maria
  • BLAUKAT, Andree
  • BURGDORF, Lars, Thore
Common Representative
  • MERCK PATENT GMBH
Priority Data
10 2005 011 058.410.03.2005DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) SUBSTITUIERTE TETRAHYDRO-PYRROLO-CHINOLINDERIVATE ALS KINASEMODULATOREN, SPEZIELL DER TYROSIN- UND RAF-KINASEN
(EN) SUBSTITUTED TETRAHYDROPYRROLOQUINOLINE DERIVATIVES AS KINASE MODULATORS, ESPECIALLY TYROSINE KINASE AND RAF KINASE MODULATORS
(FR) DERIVES DE TETRAHYDRO-PYRROLO-QUINOLEINE SUBSTITUES SERVANT DE MODULATEURS DE KINASE, PLUS SPECIALEMENT DE TYROSINE KINASES ET DE RAF-KINASES
Abstract
(DE)
Verbindung der formel (I), worin X, R1, R2 und R3 die in Anspruch 1 angegebenen Bedeutungen haben, sind Inhibitoren der Tyrosinkinasen, insbesondere TIE-2, und der RafKinasen und können u.a. zur Behandlung von Tumoren eingesetzt werden.
(EN)
Disclosed is a compound of formula (I), wherein X, R1, R2, and R3 have the meanings indicated in claim 1. Said compounds are tyrosine kinase inhibitors, particularly TIE-2 kinase inhibitors, as well as Raf kinase inhibitors and can be used for the treatment of tumors, among other things.
(FR)
La présente invention concerne des composés de formule (I) dans laquelle X, R1, R2 et R3 ont les significations énoncées dans la revendication 1. Ces composés sont des inhibiteurs des tyrosine kinases, en particulier des TIE-2, et des Raf-kinases et peuvent être utilisées entre autres pour traiter des tumeurs.
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