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1. WO2006094201 - SEMICARBAZIDE-SENSITIVE AMIDE OXIDASE INHIBITORS

Publication Number WO/2006/094201
Publication Date 08.09.2006
International Application No. PCT/US2006/007626
International Filing Date 02.03.2006
IPC
A01N 33/02 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
33Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
02Amines; Quaternary ammonium compounds
A61K 31/135 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
CPC
C07D 209/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
48with oxygen atoms in positions 1 and 3, e.g. phthalimide
Applicants
  • LA JOLLA PHARMACEUTICAL COMPANY [US]/[US] (AllExceptUS)
  • SALTER-CID, Luisa, Maria [PT]/[US] (UsOnly)
  • WANG, Eric, Y. [US]/[US] (UsOnly)
  • COCKERILL, Keith [US]/[US] (UsOnly)
  • LINNIK, Matthew, D. [US]/[US] (UsOnly)
  • VICTORIA, Edward, J. [US]/[US] (UsOnly)
Inventors
  • SALTER-CID, Luisa, Maria
  • WANG, Eric, Y.
  • COCKERILL, Keith
  • LINNIK, Matthew, D.
  • VICTORIA, Edward, J.
Agents
  • CERPA, Robert, K.
Priority Data
60/658,11002.03.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SEMICARBAZIDE-SENSITIVE AMIDE OXIDASE INHIBITORS
(FR) INHIBITEURS DE L'AMINE OXYDASE SENSIBLE AUX SEMICARBAZIDES (SSAO) ET ADHESION INDUITE PAR VAP-1 UTILISEE POUR LE TRAITEMENT DE MALADIES
Abstract
(EN)
Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylhydrazine compounds, hydroxylamine (aminooxy) compounds, and other compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis.
(FR)
Compositions et procédés d'utilisation de compositions pour le traitement de maladies inflammatoires et de troubles immuns. Les composés d'allylhydrazine, les composés d'hydroxylamine (aminooxy) et d'autres composés sont des inhibiteurs de l'amine oxydase sensible aux semicarbazides (SSAO) et/ou de la protéine 1 d'adhésion vasculaire (VAP-1). Les composés trouvent une application thérapeutique dans la suppression des inflammations et des réponses inflammatoires et dans le traitement de différents troubles, y compris la sclérose en plaques.
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