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1. WO2006093053 - NOVEL PD MARKER FOR HISTONE DEACETYLASE INHIBITOR

Publication Number WO/2006/093053
Publication Date 08.09.2006
International Application No. PCT/JP2006/303472
International Filing Date 24.02.2006
IPC
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
C12N 9/99 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
99Enzyme inactivation by chemical treatment
C12Q 1/02 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
C12Q 1/44 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
34involving hydrolase
44involving esterase
G01N 33/15 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15Medicinal preparations
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
CPC
C12N 9/99
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
99Enzyme inactivation by chemical treatment
C12Q 1/48
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
48involving transferase
G01N 33/502
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005involving human or animal cells
5008for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
502for testing non-proliferative effects
Applicants
  • アステラス製薬株式会社 ASTELLAS PHARMA INC. [JP]/[JP] (AllExceptUS)
  • 松岡 秀明 MATSUOKA, Hideaki [JP]/[JP] (UsOnly)
  • 石井 芳則 ISHII, Yoshinori [JP]/[JP] (UsOnly)
  • 松田 香里 MATSUDA, Kaori [JP]/[JP] (UsOnly)
  • 荒森 一朗 ARAMORI, Ichiro [JP]/[JP] (UsOnly)
  • 森 泰亮 MORI, Hiroaki [JP]/[JP] (UsOnly)
Inventors
  • 松岡 秀明 MATSUOKA, Hideaki
  • 石井 芳則 ISHII, Yoshinori
  • 松田 香里 MATSUDA, Kaori
  • 荒森 一朗 ARAMORI, Ichiro
  • 森 泰亮 MORI, Hiroaki
Agents
  • 森田 拓 MORITA, Hiroshi
Priority Data
2005-05754702.03.2005JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) NOVEL PD MARKER FOR HISTONE DEACETYLASE INHIBITOR
(FR) NOUVEAU MARQUEUR PD POUR INHIBITEUR D’HISTONE DEACETYLASE
(JA) ヒストンデアセチラーゼ阻害剤の新規PDマーカー
Abstract
(EN)
It is intended to provide a method for evaluating the medicinal effect of a histone deacetylase (HDAC) inhibitor, comprising the steps of: (a) preparing a cell expressing CPSF5 protein; (b) bringing the cell into contact with an HDAC inhibitor; (c) measuring the acetylation level of CPSF5 protein in the cell; and (d) comparing the acetylation level measured in the step (c) with the measured acetylation level of CPSF5 protein in a control cell that has not been brought into contact with the HDAC inhibitor.
(FR)
La présente invention concerne un procédé destiné à évaluer l’effet médicinal d’un inhibiteur d’histone déacétylase (HDAC) comprenant les étapes consistant à : (a) préparer une cellule exprimant la protéine CPSF5 ; (b) mettre la cellule en contact avec un inhibiteur HDAC ; (c) mesurer le niveau d’acétylation de la protéine CPSF5 dans la cellule ; et (d) comparer le niveau d'acétylation mesuré lors de l'étape (c) avec le niveau d'acétylation de la protéine CPSF5 dans une cellule témoin n'ayant pas encore été mise en contact avec l’inhibiteur HDAC.
(JA)
 ヒストンデアセチラーゼ(HDAC)阻害剤の薬効を評価する方法であって、該方法は、以下:(a)CPSF5タンパク質を発現する細胞を調製する工程;(b)該細胞にHDAC阻害剤を接触させる工程;(c)該細胞のCPSF5タンパク質のアセチル化レベルを測定する工程;および(d)工程(c)において測定した該アセチル化レベルを、該HDAC阻害剤を接触させないコントロール細胞について測定した該細胞のCPSF5タンパク質のアセチル化レベルと比較する工程を包含する、方法。
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