Processing

Please wait...

Settings

Settings

Goto Application

1. WO2006092902 - RADIOACTIVE HALOGEN-LABELED PHENYLOXYANILINE DERIVATIVES

Publication Number WO/2006/092902
Publication Date 08.09.2006
International Application No. PCT/JP2005/024075
International Filing Date 28.12.2005
IPC
C07C 233/25 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
16having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
24with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
25having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
A61K 51/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
C07B 59/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59Introduction of isotopes of elements into organic compounds
CPC
A61K 51/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
C07B 2200/05
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
05Isotopically modified compounds, e.g. labelled
C07B 59/001
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59Introduction of isotopes of elements into organic compounds ; ; Labelled organic compounds per se
001Acyclic or carbocyclic compounds
C07C 233/88
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
88having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
Applicants
  • 大正製薬株式会社 TAISHO PHARMACEUTICAL CO., LTD. [JP]/[JP] (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW)
  • 独立行政法人 放射線医学総合研究所 NATIONAL INSTITUTE OF RADIOLOGICAL SEIENCES [JP]/[JP] (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW)
  • 鈴木 和年 SUZUKI, Kazutoshi [JP]/[JP] (UsOnly)
  • 須原 哲也 SUHARA, Tetsuya [JP]/[JP] (UsOnly)
  • クリスター ハルディン CHRISTAR, Halldin [SE]/[JP] (UsOnly)
  • 張 明栄 ZHANG, Ming-Rong [CN]/[JP] (UsOnly)
  • 中里 篤郎 NAKAZATO, Atsuro [JP]/[JP] (UsOnly)
Inventors
  • 鈴木 和年 SUZUKI, Kazutoshi
  • 須原 哲也 SUHARA, Tetsuya
  • クリスター ハルディン CHRISTAR, Halldin
  • 張 明栄 ZHANG, Ming-Rong
  • 中里 篤郎 NAKAZATO, Atsuro
Agents
  • 浅村 皓 ASAMURA, Kiyoshi
Priority Data
2005-05252728.02.2005JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) RADIOACTIVE HALOGEN-LABELED PHENYLOXYANILINE DERIVATIVES
(FR) DERIVES DE PHENYLOXYANILINE MARQUES PAR UN HALOGENE RADIOACTIF
(JA) 放射性ハロゲン標識フェニルオキシアニリン誘導体
Abstract
(EN)
A radioactive halogen-labeled phenyoxyaniline derivative represented by the following formula: wherein R1 represents a group such as an alkyl group; X1, X2, X3 and X4 represent each a hydrogen atom, an alkyl group, an alkoxy group, an alkoxy group carrying 11C introduced thereinto or a radioactive halogen atom, provided that at least one of X1, X2, X3 and X4 represents an alkoxy group carrying 11C introduced thereinto or a radioactive halogen atom; which is a compound useful as a PBR ligand having a high affinity and a high selectivity. In in vitro measurement of PBR, a PBR ligand having a high affinity and a high selectivity is labeled with a radioactive halogen nuclear species so as to enable the measurement of PBR in vivo with the use of means including not only PET but also SPECT. Thus, a compound which is useful in early diagnosing, preventing and treating diseases such as Alzheimer type dementia can be obtained.
(FR)
L’invention a trait à un dérivé de phényoxyaniline marqué par un halogène radioactif représenté par la formule suivante : R1 représente un groupe tel que le groupe alkyle ; X1, X2, X3 et X4 représentent chacun un atome d’hydrogène, un groupe alkyle, un groupe alcoxy, un groupe alcoxy portant 11C qui y a été introduit ou un atome d’halogène radioactif, à condition qu’au moins l’un des X1, X2, X3 et X4 représente un groupe alcoxy portant 11C qui y a été introduit ou un atome d’halogène radioactif. Ce dérivé est un composé utile en tant que ligand du PBR possédant une forte affinité et une grande sélectivité. Lors de la mesure in vitro du PBR, un ligand du PBR possédant une forte affinité et une grande sélectivité est marqué par un halogène radioactif de type nucléaire de manière à permettre la mesure du PBR in vivo en employant des moyens comprenant non seulement la tomographie par émission de positions mais également la gammatomographie. Ainsi, l’on obtient un composé qui se révèle utile lors de diagnostics précoces, pour prévenir et traiter des maladies telles que les démences de type Alzheimer.
(JA)
not available
Latest bibliographic data on file with the International Bureau