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1. WO2006092809 - PROCESS FOR PRODUCING POLYMORPH FORM (I) OF l-BENZYL-4- [(5, 6-DIMETHOXY-l-INDANONE) -2YL] METHYL PIPERIDINE HYDROCHLORIDE (DONEPEZIL HYDROCHLORIDE)

Publication Number WO/2006/092809
Publication Date 08.09.2006
International Application No. PCT/IN2005/000462
International Filing Date 23.12.2005
Chapter 2 Demand Filed 14.08.2006
IPC
C07D 211/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
30with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
32by oxygen atoms
CPC
C07D 211/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
30with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
32by oxygen atoms
Applicants
  • USV LIMITED [IN]/[IN] (AllExceptUS)
  • NAIDU, Avinash Venkatraman [IN]/[IN] (UsOnly)
  • TARUR, Venkatasubramanian Radhakrishnan [IN]/[IN] (UsOnly)
  • SATHE, Dhanajay Govind [IN]/[IN] (UsOnly)
  • AHER, Umesh Parashram [IN]/[IN] (UsOnly)
  • SAWANT, Kamlesh Digambar [IN]/[IN] (UsOnly)
Inventors
  • NAIDU, Avinash Venkatraman
  • TARUR, Venkatasubramanian Radhakrishnan
  • SATHE, Dhanajay Govind
  • AHER, Umesh Parashram
  • SAWANT, Kamlesh Digambar
Agents
  • LAKSHMIKUMARAN, Varadhachari
Priority Data
11/072,16904.03.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PRODUCING POLYMORPH FORM (I) OF l-BENZYL-4- [(5, 6-DIMETHOXY-l-INDANONE) -2YL] METHYL PIPERIDINE HYDROCHLORIDE (DONEPEZIL HYDROCHLORIDE)
(FR) PROCÉDÉ DE FABRICATION DE FORME POLYMORPHE (I) D’HYDROCHLORURE PIPÉRIDINE DE l-BENZYLE-4- [(5, 6-DIMÉTHOXY-l-INDANONE) -2YL] MÉTHYLE (HYDROCHLORURE DE DONÉPÉZILE)
Abstract
(EN)
The proces for making substantially pure Donepezil Hydrochloride Form (I) from Donepezil Oxalate and Donepezil Hydrochloride Form (VI) comprising dissolving a Donepezil salt in water and basifying the solution; extracting the Donepezil base with a halogenated organic solvent and acidifying with aqueous hydrochloride; evaporating and subsequently adding a suitable alcoholic solvent; cooling the solution containing the alchoholic solvent; adding n-hexane as an anti-solvent to precipitate; and drying the product to obtain Donepezil hydrochloride Form (I).
(FR)
L’invention concerne un procédé de fabrication d’une forme sensiblement pure d’hydrochlorure de donépézile (I) à partir d’oxalate de donépézile et d'une forme d’hydrochlorure de donépézile (VI) consistant à dissoudre un sel de donépézile dans l’eau et à basifier la solution ; à extraire la base de donépézile avec un solvant organique halogéné et à acidifier avec un hydrochlorure aqueux ; à évaporer et ensuite à ajouter un solvant d’alcool adéquat ; à refroidir la solution contenant le solvant d’alcool ; à ajouter un n-hexane comme anti-solvant pour créer une précipitation ; et à sécher le produit pour obtenir une forme d’hydrochlorure de donépézile (I).
Also published as
Latest bibliographic data on file with the International Bureau