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1. WO2006092640 - ANTIPROLIFERATIVE PEPTIDES CONTAINING THE MOTIF PHE-TRP-LEU, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF

Publication Number WO/2006/092640
Publication Date 08.09.2006
International Application No. PCT/HU2005/000069
International Filing Date 28.06.2005
Chapter 2 Demand Filed 11.11.2006
IPC
C07K 5/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 5/0812
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
0802with the first amino acid being neutral
0812and aromatic or cycloaliphatic
C07K 5/1016
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
1002with the first amino acid being neutral
1016and aromatic or cycloaliphatic
C07K 5/1019
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
1019with the first amino acid being basic
C07K 5/1024
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
1024with the first amino acid being heterocyclic
C07K 7/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
22Tachykinins, e.g.; Eledoisins ; , Substance P; Related peptides
Applicants
  • OROSZ, Antal [HU]/[HU]
  • SZABÓ, Andrea [HU]/[HU] (UsOnly)
  • SZEMÁN, Gabriella [HU]/[HU] (UsOnly)
  • PENKE, Botond [HU]/[HU] (UsOnly)
  • SOMLAI, Csaba [HU]/[HU] (UsOnly)
  • JANÁKI, Tamás [HU]/[HU] (UsOnly)
Inventors
  • OROSZ, Antal
  • SZABÓ, Andrea
  • SZEMÁN, Gabriella
  • PENKE, Botond
  • SOMLAI, Csaba
  • JANÁKI, Tamás
Agents
  • DANUBIA PATENT AND TRADEMARK ATTORNEYS
Priority Data
P050027003.03.2005HU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIPROLIFERATIVE PEPTIDES CONTAINING THE MOTIF PHE-TRP-LEU, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF
(FR) PEPTIDES D'ANTIPROLIFERATION CONTENANT LE MOTIF PHE-TRP-LEU, COMPOSITIONS PHARMACEUTIQUES ET UTILISATIONS MEDICALES DE CELLES-CI
Abstract
(EN)
The invention relates to a compound of formula (I) V-X-Phe-Trp-Leu-Y-Z wherein V means H, pHOPA, Suc or an amino protective group, X means one or more amino acids selected from the group consisting of Arg, His, Lys, Phe, Trp, Tyr and substituted derivatives thereof, or a direct bond, means an amino acid attached through normal or reduced peptide bond and selected from the group consisting of Ala, ß-Ala, Gly, Ile, Leu, Val and substituted derivatives thereof, or a direct bond, Z means OH, NH2, substituted NH2, wherein the substituent is alkyl, alkenyl, alkynyl, alkoxy, hydroxyalkyl or cycloalkyl each containing from 1 to 8 carbon atoms. The invention relates furthermore to a process for the preparation said compounds and pharmaceutical compositions containing the same for traitment of cancer.
(FR)
L'invention concerne un composé de la formule (I) V-X-Phe-Trp-Leu-Y-Z où V signifie H, pHOPA, Suc ou un groupe de protection aminé, X signifie un ou plusieurs acides aminés sélectionnés parmi le groupe consistant en Arg, His, Lys, Phe, Trp, Tyr et les dérivés substitués de ceux-ci, ou bien une liaison directe, Y signifie un acide aminé fixé par une liaison peptide normale ou réduite et sélectionné parmi le groupe consistant en Ala, ß-Ala, Gly, Ile, Leu, Val et les dérivés substitués de ceux-ci, ou bien une liaison directe, Z signifie OH, NH2, NH2 substitué, où le substituant est un alkyle, un alcényle, un alcyinyle, un alcoxy, un hydroxyalkyle ou un cycloalkyle contenant chacun 1 à 8 atomes de carbone, ou un groupe de protection carboxyle. L'invention concerne de plus un procédé de préparation desdits composés et des desdites compositions pharmaceutiques contenant lesdits composés pour le traitement du cancer.
Also published as
EP5754790
Latest bibliographic data on file with the International Bureau