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1. WO2006092622 - TREATMENT OF CYTOKINE DYSREGULATION BY USING SN-2 GAMMA-LINOLENOYL, GAMMA-DIHOMOLINOLENOYL OR ARACHIDONOYL PATTY ACID GLYCEROL MONOESTERS

Publication Number WO/2006/092622
Publication Date 08.09.2006
International Application No. PCT/GB2006/000778
International Filing Date 02.03.2006
IPC
A61K 31/232 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
23of acids having a carboxyl group bound to a chain of seven or more carbon atoms
232having three or more double bonds, e.g. etretinate
CPC
A61K 31/232
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
23of acids having a carboxyl group bound to a chain of seven or more carbon atoms
232having three or more double bonds, e.g. etretinate
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
Applicants
  • BTG INTERNATIONAL LIMITED [GB]/[GB] (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW)
  • HARBIGE, Laurence, S. [GB]/[GB] (UsOnly)
  • LEACH, Michael, J. [GB]/[GB] (UsOnly)
  • BARRACLOUGH, Paul [GB]/[GB] (UsOnly)
Inventors
  • HARBIGE, Laurence, S.
  • LEACH, Michael, J.
  • BARRACLOUGH, Paul
Agents
  • DOLAN, Anthony, Patrick
Priority Data
0504333.602.03.2005GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TREATMENT OF CYTOKINE DYSREGULATION BY USING SN-2 GAMMA-LINOLENOYL, GAMMA-DIHOMOLINOLENOYL OR ARACHIDONOYL PATTY ACID GLYCEROL MONOESTERS
(FR) TRAITEMENT DU DÉRÈGLEMENT DES CYTOKINES PAR L'EMPLOI DE MONOESTERS SN-2 DE GLYCÉROL D'ACIDES GRAS DE GAMMA-LINOLÉNOYLE, GAMMA-DIHOMOLINOLÉNOYLE OU ARACHIDONOYLE
Abstract
(EN)
A method of treating a patient in need of therapy for a cytokine dysregulation comprising administering to that patient a therapeutically effective dose of a monoglyceride or metabolic precursor thereof of general formula (I), wherein R1 is the a fatty acyl group of an essential poyunsaturated fatty acid selected from ϝ-linolenoyl, ϝ-dihomolinolenoyl and arachidonoyl.
(FR)
La présente invention concerne une méthode de traitement d'un patient nécessitant un traitement du dérèglement des cytokines, ladite méthode comprenant l'administration à ce patient d'une dose thérapeutiquement significative d'un monoglycéride ou d'un précurseur métabolique dudit monoglycéride de formule générale (I), où R1 est un groupement acyle gras provenant d'un acide gras essentiellement polyinsaturé sélectionné parmi le ϝ-linolénoyle, le ϝ-dihomolinolénoyle et l’arachidonoyle.
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