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Machine translation
1. (WO2006091776) BIOMARKERS FOR PREDICTING PROSTATE CANCER PROGRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/091776    International Application No.:    PCT/US2006/006527
Publication Date: 31.08.2006 International Filing Date: 24.02.2006
IPC:
C12Q 1/68 (2006.01)
Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US/US]; 75 Francis Street, Boston, MA 02115 (US) (For All Designated States Except US).
RUBIN, Mark, A. [US/US]; (US) (For US Only).
DEMICHELIS, Francesca [IT/US]; (US) (For US Only)
Inventors: RUBIN, Mark, A.; (US).
DEMICHELIS, Francesca; (US)
Agent: JARRELL, Brenda, Herschbach; Choate, Hall & Stewart, Two International Place, Boston, MA 02110 (US)
Priority Data:
60/656,489 25.02.2005 US
Title (EN) BIOMARKERS FOR PREDICTING PROSTATE CANCER PROGRESSION
(FR) BIOMARQUEURS DESTINES A PREDIRE LA PROGRESSION D'UN CANCER DE LA PROSTATE
Abstract: front page image
(EN)The present invention relates to the identification and use of gene expression profiles with clinical relevance to prostate cancer. In particular, the invention provides the identity of genes whose expression, at the transcriptional and protein levels, is correlated with prostate cancer progression. Methods and kits are described for using these gene expression profiles in the study and/or diagnosis of prostate cancer diseases, in the prediction of prostate cancer progression, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that target these genes or their protein products, in particular for the development of therapeutics for modulating prostate cancer progression.
(FR)La présente invention se rapporte à l'identification et à l'utilisation de profils d'expression génétique présentant une pertinence clinique pour le cancer de la prostate. En particulier, l'invention concerne l'identité de gènes dont l'expression, sur les plans transcriptionnel et protéique, est en corrélation avec une progression du cancer de la prostate. L'invention a également trait à des procédés et à des kits permettant d'utiliser lesdits profils d'expression génétique pour l'étude et/ou le diagnostic de maladies cancéreuses de la prostate, pour la prédiction de la progression du cancer de la prostate, et pour la sélection et/ou le suivi de schémas thérapeutiques. L'invention se rapporte aussi au criblage de médicaments qui ciblent lesdits gènes ou leurs produits protéiques, en particulier pour la mise au point de traitements destinés à moduler la progression du cancer de la prostate.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)