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Machine translation
1. (WO2006091542) USE OF SILDENAFIL, VARDENAFIL AND OTHER 5-PHOSPHODIESTERASE INHIBITORS TO ENHANCE PERMEABILITY OF THE ABNORMAL BLOOD-BRAIN BARRIER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/091542    International Application No.:    PCT/US2006/005980
Publication Date: 31.08.2006 International Filing Date: 22.02.2006
IPC:
A01N 43/42 (2006.01), A01N 43/50 (2006.01), A61K 31/44 (2006.01), A61K 31/415 (2006.01)
Applicants: CEDARS-SINAI MEDICAL CENTER [US/US]; 8700 Beverly Boulevard, Los Angeles, California 90048 (US) (For All Designated States Except US).
BLACK, Keith [US/US]; (US) (For US Only)
Inventors: BLACK, Keith; (US)
Agent: LEVY, Seth, D.; Suite 2400, 865 South Figueroa Street, Los Angeles, California 90017-2566 (US)
Priority Data:
60/655,075 22.02.2005 US
Title (EN) USE OF SILDENAFIL, VARDENAFIL AND OTHER 5-PHOSPHODIESTERASE INHIBITORS TO ENHANCE PERMEABILITY OF THE ABNORMAL BLOOD-BRAIN BARRIER
(FR) UTILISATION DU SILDENAFIL, DU VARDENAFIL ET D'AUTRES INHIBITEURS DE LA 5-PHOSPHODIESTERASE POUR AUGMENTER LA PERMEABILITE D'UNE BARRIERE SANG /CERVEAU ANORMALE
Abstract: front page image
(EN)This invention relates to compositions, methods and kits for enhancing the permeability of the blood-brain barrier. Particularly, compositions comprising 5-phosphodiesterase inhibitors, such as sildenafil, vardenafil, or tadalafil, when administered to a mammal, will selectively enhance the permeability of the blood-brain barrier in abnormal brain tissue. This selective enhancement allows for selective delivery of therapeutic agents to treat the abnormal brain tissue; for example, a brain tumor.
(FR)L'invention porte sur des compositions, méthodes et trousses augmentant la perméabilité de la barrière sang/cerveau, et en particulier sur des compositions comprenant des inhibiteurs de la 5-phosphodiestérase tels que le sildénafil, le vardénafil, ou le tadalafil, qui, administrés à un mammifère, en renforceront sélectivement la perméabilité de la barrière sang/cerveau de tissus anormaux du cerveau. Cet accroissement sélectif permet l'administration sélective d'agents thérapeutiques traitant les tissus anormaux du cerveau tels que les tumeurs.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)