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1. (WO2006091209) BISPECIFIC BINDING AGENTS FOR MODULATING BIOLOGICAL ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/091209    International Application No.:    PCT/US2005/015638
Publication Date: 31.08.2006 International Filing Date: 05.05.2005
IPC:
A61K 39/395 (2006.01), C12P 21/08 (2006.01)
Applicants: MERRIMACK PHARMACEUTICALS, INC. [US/US]; 101 Binney Street, Cambridge, Massachusetts 02142 (US) (For All Designated States Except US).
NIELSEN, Ulrik, B. [DK/US]; (US) (For US Only).
SCHOEBERL, Birgit, M. [DE/US]; (US) (For US Only)
Inventors: NIELSEN, Ulrik, B.; (US).
SCHOEBERL, Birgit, M.; (US)
Agent: HYMAN, Laurence, J.; Townsend And Townsend And Crew Llp, Two Embarcadero Center, 8th Floor, San Francisco, California 94111-3834 (US)
Priority Data:
60/655,836 23.02.2005 US
Title (EN) BISPECIFIC BINDING AGENTS FOR MODULATING BIOLOGICAL ACTIVITY
(FR) AGENTS DE LIAISON BISPECIFIQUES UTILISES POUR MODULER UNE ACTIVITE BIOLOGIQUE
Abstract: front page image
(EN)Methods for improving the specific binding ability of bispecific binding compositions are described. The bispecific binding compositions are able to target cells by a high affinity targeting domain to a target cell surface marker and a low affinity binding domain that binds specifically to a second cell surface marker, wherein the binding of each domain to its respective cell surface marker increases or decreases, as desired, the biological activity of the respective cell surface markers. The invention further provides bispecific binding agents for use in the methods, as well as uses for the agents.
(FR)Cette invention concerne des procédés permettant d'améliorer la capacité de liaison bispécifique de compositions de liaison bispécifiques. Les compositions de liaison bispécifiques peuvent cibler des cellules par un domaine de ciblage à haute affinité sur un marqueur de surface de cellules cibles et un domaine de liaison à faible affinité qui se lie spécifiquement à un second marqueur de surface de cellules, la liaison de chaque domaine à son marqueur de surface de cellules respectif augmentant ou réduisant, selon les besoins, l'activité biologique des marqueurs de surface de cellules respectifs. Cette invention concerne également des agents de liaison bispécifiques utilisés dans les procédés, ainsi que des utilisations de ces agents.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)