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1. (WO2006090932) SURROGATE MARKER FOR SULFONAMIDE COMPOUND
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/090932    International Application No.:    PCT/JP2006/304221
Publication Date: 31.08.2006 International Filing Date: 28.02.2006
IPC:
A61K 31/18 (2006.01), A61K 31/343 (2006.01), A61K 31/381 (2006.01), A61K 31/404 (2006.01), A61K 31/47 (2006.01), A61K 31/498 (2006.01), A61K 31/64 (2006.01), A61K 39/395 (2006.01), A61K 45/00 (2006.01), A61P 1/04 (2006.01), A61P 3/00 (2006.01), A61P 3/10 (2006.01), A61P 25/00 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01), A61P 37/02 (2006.01), A61P 43/00 (2006.01), C07D 209/30 (2006.01), C07D 215/48 (2006.01), C07D 241/44 (2006.01), C07D 333/34 (2006.01), C12Q 1/02 (2006.01), C12Q 1/68 (2006.01), G01N 33/53 (2006.01), C07K 16/24 (2006.01), C12N 9/99 (2006.01), C12N 15/09 (2006.01)
Applicants: EISAI R & D MANAGEMANT CO., LTD. [JP/JP]; 6-10, Koishikawa 4-chome, Bunkyo-ku, Tokyo, 1128088 (JP) (For All Designated States Except US).
OWA, Takashi [JP/JP]; (JP) (For US Only).
OZAWA, Yoichi [JP/JP]; (JP) (For US Only).
ONO, Naoto [JP/JP]; (JP) (For US Only)
Inventors: OWA, Takashi; (JP).
OZAWA, Yoichi; (JP).
ONO, Naoto; (JP)
Agent: KOBAYASHI, Hiroshi; c/o ABE, IKUBO & KATAYAMA, Fukuoka Bldg. 9th Fl. 8-7, Yaesu 2-chome, Chuo-ku, Tokyo 1040028 (JP)
Priority Data:
2005-054475 28.02.2005 JP
Title (EN) SURROGATE MARKER FOR SULFONAMIDE COMPOUND
(FR) MARQUEUR DE SUBSTITUTION POUR COMPOSE DE SULFONAMIDE
(JA) スルホンアミド化合物の代理マーカー
Abstract: front page image
(EN)A method of evaluating the effect of a sulfonamide compound on the expression of integrin which involves: (a) the step of measuring the expression amount of integrin in platelets collected from a patient to whom the above-described sulfonamide compound has been administered; and (b) the step of evaluating the effect of the above-described compound on the expression of integrin in cells other than the platelets based on the expression amount measured above.
(FR)Cette invention renvoie à un procédé visant à évaluer l'effet d'un composé de sulfonamide sur l'expression de l'intégrine, qui comprend: (a) l'étape consistant à mesurer l'expression du montant d'intégrine dans des plaquettes prélevées sur un patient auquel on a administré le composé de sulfonamide décrit ci-dessus ; et (b), l'étape consistant à évaluer l'effet du composé décrit ci-dessus sur l'expression de l'intégrine dans des cellules autres que les plaquettes, en se fondant sur le montant de l'expression mesuré ci-dessus.
(JA)インテグリンの発現に対するスルホンアミド化合物の作用を評価する方法であって、(a)前記スルホンアミド化合物の投与を受けた患者から採取された血小板におけるインテグリンの発現量を測定する工程と、(b)測定された発現量に基づき血小板以外の細胞におけるインテグリンの発現に対する前記化合物の作用を評価する工程と、を含む、前記方法。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)