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1. (WO2006090848) METHOD FOR DETECTION OF NUCLEOTIDE POLYMORPHISM IN GENE USED FOR DIAGNOSING EFFECT OF METHOTREXATE THERAPY IN RHEUMATOID ARTHRITIS PATIENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/090848    International Application No.:    PCT/JP2006/303467
Publication Date: 31.08.2006 International Filing Date: 24.02.2006
IPC:
C12Q 1/68 (2006.01), A61K 31/519 (2006.01), A61P 19/02 (2006.01), A61P 29/00 (2006.01), C12N 15/09 (2006.01), C07D 475/10 (2006.01)
Applicants: KANSAI TECHNOLOGY LICENSING ORGANIZATION CO., LTD. [JP/JP]; 93, Chudoji Awata-cho, Shimogyo-ku, Kyoto-shi, Kyoto 6008815 (JP) (For All Designated States Except US).
TAKAHASHI, Kenji [JP/JP]; (JP) (For US Only).
TOKUNAGA, Daisaku [JP/JP]; (JP) (For US Only).
KUBO, Toshikazu [JP/JP]; (JP) (For US Only)
Inventors: TAKAHASHI, Kenji; (JP).
TOKUNAGA, Daisaku; (JP).
KUBO, Toshikazu; (JP)
Agent: SAEGUSA, Eiji; Kitahama TNK Building 1-7-1, Doshomachi, Chuo-ku Osaka-shi, Osaka 5410045 (JP)
Priority Data:
2005-050621 25.02.2005 JP
Title (EN) METHOD FOR DETECTION OF NUCLEOTIDE POLYMORPHISM IN GENE USED FOR DIAGNOSING EFFECT OF METHOTREXATE THERAPY IN RHEUMATOID ARTHRITIS PATIENT
(FR) PROCÉDÉ DE DÉTECTION DU POLYMORPHISME D’UN NUCLÉOTIDE DANS UN GÈNE UTILISÉ POUR DIAGNOSTIQUER L'EFFET D'UNE THÉRAPIE AU MÉTHOTREXATE CHEZ UN PATIENT ATTEINT DE POLYARTHRITE RHUMATOÏDE
(JA) 関節リウマチ患者におけるメトトレキセート療法での効果診断遺伝子の塩基多型の検出方法
Abstract: front page image
(EN)A method for determining an effect of methotrexate in a rheumatoid arthritis patient and a method for determining the amount to be administered to the patient before the administration, both characterized by detecting a single nucleotide polymorphism in nucleotide 3435 in exon 26 of ABCB1 gene.
(FR)La présente invention concerne un procédé pour déterminer l’effet du méthotrexate chez un patient atteint de polyarthrite rhumatoïde, ainsi qu'un procédé pour déterminer la quantité à administrer au patient avant l'administration, les deux procédés caractérisés par la détection d’un seul polymorphisme de nucléotide dans le nucléotide 3435 de l’exon 26 du gène ABCB1.
(JA) 本発明は、ABCB1遺伝子のエクソン26の3435番目の塩基の塩基多型(SNP)を検出することを特徴とする関節リウマチ患者におけるメトトレキセートの効果,投与量を投与前に判定する方法に関する。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)