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1. (WO2006090816) METHOD OF CONSTRUCTING LIPOSOME VACCINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/090816    International Application No.:    PCT/JP2006/303371
Publication Date: 31.08.2006 International Filing Date: 24.02.2006
IPC:
A61K 39/12 (2006.01), A61K 9/127 (2006.01), A61K 39/145 (2006.01), A61K 39/245 (2006.01), A61K 47/24 (2006.01), A61P 31/12 (2006.01), A61P 31/16 (2006.01), A61P 31/20 (2006.01), A61P 31/22 (2006.01)
Applicants: MIE UNIVERSITY [JP/JP]; 1577, Kurimamachiya-cho, Tsu-shi, Mie 5148507 (JP) (For All Designated States Except US).
MEDICAL & BIOLOGICAL LABORATORIES CO., LTD. [JP/JP]; 5th Floor, Sumitomoshoji-Marunouchi bld., 5-10, Marunouchi 3-chome, Naka-ku, Nagoya-shi, Aichi 4600002 (JP) (For All Designated States Except US).
YOSHIMURA, Tetsuro [JP/JP]; (JP) (For US Only).
MIYAZAKI, Teruo [JP/JP]; (JP) (For US Only).
YASUTOMI, Yasuhiro [JP/JP]; (JP) (For US Only)
Inventors: YOSHIMURA, Tetsuro; (JP).
MIYAZAKI, Teruo; (JP).
YASUTOMI, Yasuhiro; (JP)
Agent: KOBAYASHI, Youhei; KY International Patent Firm, Win's bld. 2F., 4-44, Chuou-cho, Kuwana-shi, Mie 5110068 (JP)
Priority Data:
2005-049867 25.02.2005 JP
Title (EN) METHOD OF CONSTRUCTING LIPOSOME VACCINE
(FR) PROCÉDÉ DE FABRICATION DE VACCIN AU LIPOSOME
(JA) リポソームワクチンの作製法
Abstract: front page image
(EN)To provide a method of producing a liposome vaccine which can be maintained in a stable state over a long period of time and has an effective immunologically active competence. To achieve this object, a liposome vaccine is produced by ultrasonically treating a phospholipid coexisting with a virus which has been ultrasonically treated. In this liposome vaccine, the virus can be maintained in a stable state of coexisting with the double membrane of the phospholipid constituting the liposomes over a long period of time and sustains an immunological competence which is effective for fishes and mammals.
(FR)L’invention concerne un procédé de fabrication d’un vaccin au liposome que l’on peut maintenir à l’état stable sur une longue période et ayant une compétence efficace active du point de vue immunologique. Pour obtenir ces caractéristiques, on élabore un vaccin au liposome par traitement ultrasonique d’un phospholipide coexistant avec un virus que l’on a traité par ultrasons. Dans ce vaccin au liposome, le virus peut être maintenu dans un état stable de coexistence avec la double membrane du phospholipide constituant les liposomes sur une période prolongée et présente une compétence immunologique qui est efficace pour les poissons et les mammifères.
(JA) 長期間に渡って安定的に維持できると共に、有効な免疫活性能を有するリポソームワクチンの製造法を提供することを課題とする。この課題は、リン脂質と、超音波処理したウイルスとを共存させた状態で超音波処理することにより、リポソームワクチンを作製する。このリポソームワクチンでは、ウイルスはリポソームを構成するリン脂質二重膜と共存した状態で長期間に渡って安定に維持されると共に、魚類及び哺乳類に対して有効な免疫能を有している。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)