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1. (WO2006090724) TRANSGENIC MOUSE OR TRANSGENIC RAT HAVING MUTANT TRPV3 GENE INTRODUCED THEREIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/090724    International Application No.:    PCT/JP2006/303134
Publication Date: 31.08.2006 International Filing Date: 22.02.2006
IPC:
C12N 15/00 (2006.01), A01K 67/02 (2006.01), A01K 67/027 (2006.01), C12N 15/09 (2006.01)
Applicants: Shionogi & Co., Ltd. [JP/JP]; 1-8, Doshomachi 3-chome, Chuo-ku, Osaka-shi, Osaka 5410045 (JP) (For All Designated States Except US).
ASAKAWA, Makoto [JP/JP]; (JP) (For US Only).
YOSHIOKA, Takeshi [JP/JP]; (JP) (For US Only).
TSUKAHARA, Kiyoshi [JP/JP]; (JP) (For US Only).
OSHIMA, Itsuki [JP/JP]; (JP) (For US Only).
HIRASAWA, Tsutomu [JP/JP]; (JP) (For US Only).
SUZUKI, Minoru [JP/JP]; (JP) (For US Only)
Inventors: ASAKAWA, Makoto; (JP).
YOSHIOKA, Takeshi; (JP).
TSUKAHARA, Kiyoshi; (JP).
OSHIMA, Itsuki; (JP).
HIRASAWA, Tsutomu; (JP).
SUZUKI, Minoru; (JP)
Agent: TAKAYAMA, Hirotsugu; Shionogi & Co., Ltd. Intellectual Property Department 12-4, Sagisu 5-chome Fukushima-ku, Osaka-shi Osaka 5530002 (JP)
Priority Data:
2005-046550 23.02.2005 JP
Title (EN) TRANSGENIC MOUSE OR TRANSGENIC RAT HAVING MUTANT TRPV3 GENE INTRODUCED THEREIN
(FR) SOURIS TRANSGENIQUE OU RAT TRANSGENIQUE AYANT UN GENE MUTANT TRPV3 Y ETANT INTRODUIT
(JA) 変異型TRPV3遺伝子導入トランスジェニックマウス又はトランスジェニックラット
Abstract: front page image
(EN)A genetic mutation in TRPV3 gene is now found which can cause the dominant inheritance of a trait of developing dermatitis under SPF conditions. By utilizing a mutant TRPV3 gene which has the mutation, it becomes possible to produce a transgenic mouse or rat capable of developing dermatitis spontaneously under SPF conditions.
(FR)La présente invention concerne une mutation génétique se trouvant dans le gène TRPV3 et qui peut induire l’hérédité dominante d’un caractère de développement d'une dermite dans des conditions hétéroxéniques (ci-après SPF conditions). En utilisant un gène mutant TRPV3 qui comporte la mutation, il devient possible de produire une souris ou un rat transgénique capable de développer spontanément une dermatite dans des conditions hétéroxéniques.
(JA) SPF環境下で皮膚炎を自然発症する形質を優性遺伝する、TRPV3の遺伝子変異を見出した。該変異を持った変異型TRPV3遺伝子を利用して、SPF環境下で皮膚炎を自然発症するトランスジェニックマウス及びトランスジェニックラットを作出することができる。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)