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1. (WO2006090428) METHOD FOR THE SEPARATION AND SIMULTANEOUS DIRECT DETERMINATION OF COMPOUNDS BELONGING TO AT LEAST ONE OF THE GROUPS CHOSEN AMONG PURINES AND PYRIMIDINES, N- ACETYLATED AMINO ACIDS, MONO AND DICARBOXYLIC ACIDS, SULPHURYLATED COMPOUNDS, NITROSYLATED COMPOUNDS, BIFUNCTIONAL ALDEHYDES, VITAMINS OF GROUP B, AND DERIVATIVES THER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/090428    International Application No.:    PCT/IT2006/000116
Publication Date: 31.08.2006 International Filing Date: 28.02.2006
IPC:
B01D 15/36 (2006.01), B01D 15/16 (2006.01), B01D 15/32 (2006.01), G01N 30/34 (2006.01), G01N 30/36 (2006.01), G01N 33/50 (2006.01)
Applicants: LAZZARINO, Giuseppe [IT/IT]; (IT).
TAVAZZI, Barbara [IT/IT]; (IT).
AMORINI, Angela Maria [IT/IT]; (IT).
GIARDINA, Bruno [IT/IT]; (IT).
LEONE, Paola [IT/US]; (US)
Inventors: LAZZARINO, Giuseppe; (IT).
TAVAZZI, Barbara; (IT).
AMORINI, Angela Maria; (IT).
GIARDINA, Bruno; (IT).
LEONE, Paola; (US)
Agent: GITTO, Serena; Barzanò & Zanardo Roma S.p.A., Via Piemonte, 26, I-00187 Roma (IT)
Priority Data:
RM2005A000085 28.02.2005 IT
Title (EN) METHOD FOR THE SEPARATION AND SIMULTANEOUS DIRECT DETERMINATION OF COMPOUNDS BELONGING TO AT LEAST ONE OF THE GROUPS CHOSEN AMONG PURINES AND PYRIMIDINES, N- ACETYLATED AMINO ACIDS, MONO AND DICARBOXYLIC ACIDS, SULPHURYLATED COMPOUNDS, NITROSYLATED COMPOUNDS, BIFUNCTIONAL ALDEHYDES, VITAMINS OF GROUP B, AND DERIVATIVES THER
(FR) PROCEDE PERMETTANT LA SEPARATION ET LA DETECTION DIRECTE SIMULTANEE DE COMPOSES APPARTENANT A AU MOINS UN DES GROUPES SUIVANTS: PURINES ET PYRIMIDINES, ACIDES AMINES N-ACETYLES, ACIDES MONO ET DICARBOXYLIQUES, COMPOSES SULFURYLES, COMPOSES NIRTOSYLES, ALDEHYDES BIFONCTIONNELS, VITAMINES DU GROUPE B ET DERIVES DE CEUX-CI, DA
Abstract: front page image
(EN)The present invention concerns a method for the separation and simultaneous determination of purines and pyrimidines, N-acetylated amino acids, mono and dicarboxyli&sgr; acids, sulphurylated compounds, nitrosylated compounds, bifunctional aldehydes, vitamins of group B, and derivatives thereof, in a biological sample by high performance liquid chromatography (HPLC) and related kits. In particular, the invention refers to a method for the simultaneous determination in biological samples of compounds of clinical biochemistry interest, for example, to diagnose hereditary dismetabolic pathologies, acute and chronic alterations of metabolism, tumoral pathologies.
(FR)L'invention concerne un procédé permettant la séparation et la détection directe simultanée de composés appartenant à au moins un des groupes suivants: purines et pyrimidines, acides aminés n-acétylés, acides mono et dicarboxyliques, composés sulfurylés, composés nirtosylés, aldéhydes bifonctionnels, vitamines du groupe B et dérivés de ceux-ci, dans un échantillon biologique par chromatographie liquide haute performance (HPLC), ainsi que des trousses de matériel correspondantes. L'invention concerne en particulier un procédé permettant la détection simultanée dans des échantillons biologiques de composés présentant un intérêt du point de vue de la biochimie clinique, par exemple pour le diagnostic des pathologies dismétaboliques héréditaires, des altérations aiguës et chroniques du métabolisme, et des pathologies tumorales.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Italian (IT)