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1. (WO2006090235) 5-PHENYL-PENTANOIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS FOR THE TREATMENT OF ASTHMA AND OTHER DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/090235    International Application No.:    PCT/IB2006/000349
Publication Date: 31.08.2006 International Filing Date: 21.02.2006
IPC:
C07D 249/18 (2006.01), C07D 209/48 (2006.01), C07D 237/32 (2006.01), C07D 209/12 (2006.01), C07D 239/54 (2006.01), C07D 213/64 (2006.01), C07D 265/28 (2006.01), C07D 211/88 (2006.01), C07D 207/40 (2006.01), C07D 263/58 (2006.01), C07D 239/96 (2006.01), C07D 471/04 (2006.01), C07D 401/10 (2006.01), C07D 403/10 (2006.01), A61P 11/06 (2006.01)
Applicants: RANBAXY LABORATORIES LIMITED [IN/IN]; Plot No. 90, Sector 32, Gurgaon, Haryana 122001 (IN) (For All Designated States Except US).
PALLE, Venkata, P. [US/IN]; (IN) (For US Only).
SATTIGERI, Viswajanani, Jitendra [IS/IN]; (IN) (For US Only).
KHERA, Manoj, Kumar [IN/IN]; (IN) (For US Only).
VOLETI, Sreedhara, Rao [IN/IN]; (IN) (For US Only).
RAY, Abhijit [IN/IN]; (IN) (For US Only).
DASTIDAR, Sunanda, G. [IN/IN]; (IN) (For US Only)
Inventors: PALLE, Venkata, P.; (IN).
SATTIGERI, Viswajanani, Jitendra; (IN).
KHERA, Manoj, Kumar; (IN).
VOLETI, Sreedhara, Rao; (IN).
RAY, Abhijit; (IN).
DASTIDAR, Sunanda, G.; (IN)
Common
Representative:
RANBAXY LABORATORIES LIMITED; c/o DESHMUKH, Jay R., 600 College Road East, Suite 2100, Princeton, New Jersey 08540 (US)
Priority Data:
380/Del/2005 22.02.2005 IN
Title (EN) 5-PHENYL-PENTANOIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS FOR THE TREATMENT OF ASTHMA AND OTHER DISEASES
(FR) DERIVES D'ACIDE 5-PHENYL-PENTANOIQUE EN TANT QU'INHIBITEURS DE METALLOPROTEINASE MATRICIELLE DANS LE TRAITEMENT DE L'ASTHME ET D'AUTRES MALADIES
Abstract: front page image
(EN)The present invention relates to C ompounds having the structure of Formula I: wherein n is an integer from 1 to 5; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R2 is alkenyl, allcynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR4R5, -NHC(=Y)R4, - NHC(=Y)NR5Rχ, -NHC(=O)OR4, -NHSO2R4, C(=Y)NR4R5, C(=O)OR6 [wherein Y is oxygen or sulphur], OR5, -O(C=O)NR4R5, O-acyl, S(O)mR4, -SO2N(R4)2, cyano, amidino or guanidino [wherein R4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl and m is an integer 0-2; R5 is hydrogen or R4; Rx is R4 or -SO2N(R4)2 and R6 is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl]; R3 is hydrogen, fluorine, alkyl, cycloalkylalkyl or aralkyl; A is OH, OR4, -OC(=O)NR4R5, O-acyl, NH2, NR4R5, -NHC(=Y)R4, -NHC(=Y)NR5Rx, - NHC(=O)OR4, -NHSO2R4, and to processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over-activation of an matrix metalloproteinase, using the compounds.
(FR)La présente invention concerne des composés ayant la structure de formule (I) dans laquelle n représente un entier de 1 à 5; R1 représente alkyle, alcényle, alkynyle, cycloalkyle, aryle, hétérocyclyle, hétéroaryle, aralkyle, alkoxy, aryloxy, alkenyloxy ou alkynyloxy falcutativement substitués; R2 représente alcényle, alkynyle, aryle, hétérocyclyle, hétéroaryle, cycloalkyle, NR4R5, -NHC(=Y)R4, -NHC(=Y)NR5Rx, -NHC(=O)OR4, -NHSO2R4, C(=Y)NR4R5, C(=O)OR6 [où Y représente oxygène ou soufre], OR5, -OC(=O)NR4R5, O-acyle, S(O)mR4, -SO2N(R4)2, cyano, amidino ou guanidino [où R4 représente alkyle, alcényle, alkynyle, cycloalkyle, aryle, hétérocyclyle, hétéroaryle, aralkyle, hétéroarylalkyle, hétérocyclylalkyle ou cycloalkylalkyle et m représente un entier 0-2; R5 représente hydrogène ou R4; Rx représente R4 ou -SO2N(R4)2 et R6 représente hydrogène, alkyle, cycloalkyle, aralkyle, hétéroarylalkyle, hétérocyclylalkyle ou cycloalkylalkyle]; R3 représente hydrogène, fluor, alkyle, cycloalkylalkyle ou aralkyle; A représente OH, OR4, -OC(=O)NR4R5, O-acyle, NH2, NR4R5, -NHC(=Y)R4, -NHC(=Y)NR5Rx, -NHC(=O)OR4, -NHSO2R4; et leurs procédés de synthèse. Cette invention concerne également des compositions pharmacologiques contenant les composés de la présente invention ainsi que des méthodes de traitement de l'asthme, de la polyarthrite rhumatoïde, MPOC, la rhinite, l'ostéoarthrite, la polyarthrite psoriosique, le psoriasis, la fibrose pulmonaire, l'inflammation pulmonaire, le syndrome de détresse respiratoire aigu, la parodontite, la sclérose en plaques, la gingivite, l'athérosclérose, la prolifération néointimale qui conduit à la resténose et l'insuffisance cardiaque ischémique, l'attaque cérébrale, les maladies rénales, les métastase tumorales ainsi que d'autres troubles inflammatoires caractérisés par une surexpression et une suractivation d'une métalloprotéinase matricielle, à l'aides des composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)