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1. (WO2006090224) BENZISOXAZOLE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/090224    International Application No.:    PCT/IB2006/000313
Publication Date: 31.08.2006 International Filing Date: 15.02.2006
Chapter 2 Demand Filed:    10.04.2006    
IPC:
C07D 413/12 (2006.01), C07D 413/14 (2006.01), A61K 31/454 (2006.01), A61P 9/00 (2006.01), A61P 25/00 (2006.01), A61P 25/28 (2006.01)
Applicants: PFIZER JAPAN INC. [JP/JP]; Shinjuku Bunka Quint Bldg., 3-22-7, Yoyogi, Shibuya-ku,, Tokyo 151-8589 (JP) (JP only).
NOGUCHI, Hirohide [JP/JP]; (JP) (For US Only).
SAKURADA, Isao [JP/JP]; (JP) (For US Only).
UCHIDA, Chikara [JP/JP]; (JP) (For US Only).
WAIZUMI, Nobuaki [JP/JP]; (JP) (For US Only).
PFIZER INC. [US/US]; 235 East 42nd Street, New York, NY 10017 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only)
Inventors: NOGUCHI, Hirohide; (JP).
SAKURADA, Isao; (JP).
UCHIDA, Chikara; (JP).
WAIZUMI, Nobuaki; (JP)
Agent: FULLER, Grover, F., Jr.; c/o Drouin, Stéphane, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ (GB)
Priority Data:
60/656,653 25.02.2005 US
60/715,977 09.09.2005 US
Title (EN) BENZISOXAZOLE DERIVATIVES
(FR) DERIVES DE BENZISOXAZOLE
Abstract: front page image
(EN)This invention relates to compounds of the formula (I): wherein A, B, R1, R4, m, and n are each as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central 10 nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.
(FR)L'invention concerne des composés de formule (I): dans laquelle A, B, R1, R4, m et n sont chacun tels que définis dans la description, ou un sel pharmaceutiquement acceptable de ceux-ci, ainsi que des compositions contenant ces composés et l'utilisation de ces composés dans le traitement d'un état induit par l'activité du récepteur 5-HT4, tel que, entre autres, la maladie du reflux gastro-oesophagien, les maladies gastro-intestinales, les troubles de la motilité gastrique, la dyspepsie non ulcéreuse, la dyspepsie fonctionnelle, le syndrome du côlon irritable, la constipation, la dyspepsie, l'oesophagite, les maladies gastro-oesophagiennes, les nausées, les maladies du système nerveux central, la maladie d'Alzheimer, les troubles cognitifs, les vomissements, la migraine, les maladies neurologiques, la douleur, les troubles cardio-vasculaires, tels que l'insuffisance cardiaque et l'arythmie cardiaque, le diabète et le syndrome d'apnée.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)