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Pub. No.:    WO/2006/090165    International Application No.:    PCT/GB2006/000664
Publication Date: 31.08.2006 International Filing Date: 24.02.2006
G01N 33/543 (2006.01), G01N 33/58 (2006.01)
Applicants: PRONOSTICS LIMITED [GB/GB]; Babraham Hall, Babraham, Cambridge, Cambridgeshire CB2 4AT (GB) (For All Designated States Except US).
GAREY, Caroline [GB/GB]; (GB) (For US Only).
SWARBRICK, Peter [GB/GB]; (GB) (For US Only)
Inventors: GAREY, Caroline; (GB).
Agent: GILL, Stephen; Mewburn Ellis LLP, York House, 23 Kingsway, London, Greater London WC2B 6HP (GB)
Priority Data:
0504100.9 28.02.2005 GB
Abstract: front page image
(EN)A method is provided for the detection of analytes in samples. The method makes use of a plurality of sets of particulate supports, the supports of each set carrying a unique identifier allowing them to be distinguished from the supports of the other sets. Each set of supports is partitioned from the other sets of supports. The method comprises the steps of: (a) attaching a primary analyte to the supports of all the sets, (b) introducing respective samples to the sets of supports so that each sample is associated with a corresponding unique identifier, each sample potentially containing a secondary analyte which binds to the primary analyte, (c) combining the sets of supports to form a support mixture containing supports from all of the sets, (d) introducing a reporter system to the support mixture, the reporter system being responsive to the presence of secondary analyte bound to the supports via the primary analyte, and (e) interrogating the support mixture to determine the unique identifiers of supports which have an activated reporter system in order to identify which samples contain the secondary analyte.
(FR)L’invention concerne un procédé de détection d’analytes dans des échantillons. Le procédé fait appel à une pluralité d’ensembles de supports particulaires, les supports de chaque ensemble transportant un identificateur unique permettant de les distinguer des supports des autres ensembles. Chaque ensemble de supports est séparé des autres ensembles de supports. Le procédé comprend les phases suivantes : (a) fixation d’un analyte primaire aux supports de tous les ensembles, (b) introduction des échantillons respectifs dans les ensembles de supports de sorte que chaque échantillon est associé à un identificateur unique correspondant, chaque échantillon contenant potentiellement un analyte secondaire qui se lie à l’analyte primaire, (c) combinaison des ensembles de supports pour constituer un mélange support contenant des supports provenant de tous les ensembles, (d) introduction d’un système rapporteur dans le mélange support, le système rapporteur réagissant à la présence d’analyte secondaire lié aux supports par le biais de l’analyte primaire, et (e) interrogation du mélange support pour déterminer les identificateurs uniques des supports ayant un système rapporteur activé afin d’identifier les échantillons contenant l’analyte secondaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)