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1. (WO2006089898) METABOLICALLY ENGINEERED CELLS FOR THE PRODUCTION OF RESVERATROL OR AN OLIGOMERIC OR GLYCOSIDICALLY-BOUND DERIVATIVE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/089898    International Application No.:    PCT/EP2006/060154
Publication Date: 31.08.2006 International Filing Date: 21.02.2006
Chapter 2 Demand Filed:    18.12.2006    
IPC:
C12N 9/00 (2006.01), C12N 9/02 (2006.01), C12N 9/10 (2006.01), C12N 9/88 (2006.01), C12P 7/22 (2006.01)
Applicants: FLUXOME SCIENCES A/S [DK/DK]; Diplomvej 378, DK-2800 Kgs. Lyngby (DK) (For All Designated States Except US).
KATZ, Michael [SE/SE]; (SE) (For US Only).
SMITS, Hans Peter [NL/DK]; (DK) (For US Only).
FÖRSTER, Jochen [DE/DK]; (DK) (For US Only).
NIELSEN, Jens Bredal [DK/DK]; (DK) (For US Only)
Inventors: KATZ, Michael; (SE).
SMITS, Hans Peter; (DK).
FÖRSTER, Jochen; (DK).
NIELSEN, Jens Bredal; (DK)
Agent: SMART, Peter, John; Fulwood House, 12 Fulwood Place, London, London GB WC1V 6HR (GB)
Priority Data:
0503657.9 22.02.2005 GB
Title (EN) METABOLICALLY ENGINEERED CELLS FOR THE PRODUCTION OF RESVERATROL OR AN OLIGOMERIC OR GLYCOSIDICALLY-BOUND DERIVATIVE THEREOF
(FR) CELLULES MODIFIÉES DU POINT DE VUE MÉTABOLIQUE POUR LA PRODUCTION DE RESVÉRATROL OU D'UN DÉRIVÉ OLIGOMÉRIQUE OU LIÉ DE MANIÈRE GLYCOSIDIQUE DE CELUI-CI
Abstract: front page image
(EN)A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4- hydroxylase (C4H) produces 4-coumaric acid from said trans- cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4- coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4- coumaroyl CoA, or in which L-phenylalanine- or tyrosine- ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4- coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.
(FR)Microorganisme recombiné produisant du resvératrol par une voie dans laquelle la phénylalanine ammonia-lyase (PAL) produit de l'acide trans-cinnamique à partir de phénylalanine, la cinnamate 4-hydroxylase (C4H) produit de l'acide 4-coumarique à partir dudit acide trans-cinnamique, la 4-coumarate-CoA ligase (4CL) produit de la 4-coumaroyl-CoA à partir dudit acide 4-coumarique et la resvératrol synthétase (VST) produit ledit resvératrol à partir de ladite 4-coumaroyl-CoA ou bien dans laquelle la L-phénylalanine ou tyrosine ammonia-lyase (PAL/TAL) produit de l'acide 4-coumarique, la 4-coumarate-CoA ligase (4CL) produit de la 4-coumaroyl-CoA à partir dudit acide 4-coumarique et la resvératrol synthétase (VST) produit ledit resvératrol à partir de ladite 4-coumaroyl-CoA. Le microorganisme peut être une levure, un champignon ou une bactérie dont Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger ou Aspergillus oryzae.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)