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1. (WO2006089798) 2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/089798    International Application No.:    PCT/EP2006/001801
Publication Date: 31.08.2006 International Filing Date: 27.02.2006
Chapter 2 Demand Filed:    31.10.2006    
IPC:
C07D 401/04 (2006.01), A61K 31/435 (2006.01), A61P 29/00 (2006.01)
Applicants: MERCKLE GMBH [DE/DE]; Graf-Arco-Strasse 3, 89079 Ulm (DE) (For All Designated States Except US).
ALBRECHT, Wolfgang [DE/DE]; (DE) (For US Only).
GREIM, Cornelia [DE/DE]; (DE) (For US Only).
STRIEGEL, Hans-Günter [DE/DE]; (DE) (For US Only).
TOLLMANN, Karola [DE/DE]; (DE) (For US Only).
MERCKLE, Philipp [DE/DE]; (DE) (For US Only).
LAUFER, Stefan [DE/DE]; (DE) (For US Only)
Inventors: ALBRECHT, Wolfgang; (DE).
GREIM, Cornelia; (DE).
STRIEGEL, Hans-Günter; (DE).
TOLLMANN, Karola; (DE).
MERCKLE, Philipp; (DE).
LAUFER, Stefan; (DE)
Agent: Reitstötter, Kinzebach & Partner (GbR); Sternwarstrasse 4, 81679 Munich (DE)
Priority Data:
05004369.4 28.02.2005 EP
60/656,389 28.02.2005 US
Title (EN) 2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS
(FR) DÉRIVÉS D’IMIDAZOLE DE 2-SULFINYLE ET DE 2-SULFONYLE ET LEUR UTILISATION COMME INHIBITEURS DE CYTOKINES
Abstract: front page image
(EN)The invention relates to 2-sulfinyl- or 2-sulfonyl-substituted imidazole derivatives of the formula (I) in which the radicals R1, R2, R3 and R4 have the meaning indicated in the description. The compounds of the invention have an immunomodulating and/or cytokine release-inhibiting effect and are therefore suitable for the treatment of disorders associated with an impairment of the immune system.
(FR)La présente invention concerne des dérivés d’imidazole de 2-sulfinyle et de 2-sulfonyle de la formule (I) dans laquelle les radicaux R1, R2, R3 et R4 possèdent la signification indiquée dans la description. Les composés de l’invention présentent un effet immunomodulateur et/ou d’inhibition de libération des cytokines et, par conséquent, sont appropriés pour le traitement de désordres associés aux troubles du système immunitaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)