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1. (WO2006089275) METHODS OF MAKING PHARMACOKINETICALLY IMPROVED COMPOUNDS COMPRISING FUNCTIONAL RESIDUES OR GROUPS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/089275    International Application No.:    PCT/US2006/006047
Publication Date: 24.08.2006 International Filing Date: 21.02.2006
IPC:
A61K 31/53 (2006.01), C07D 487/04 (2006.01), A61P 15/10 (2006.01)
Applicants: SURFACE LOGIX, INC. [US/US]; 50 Solders Field Place, Brighton, Massachusetts 02135 (US).
LUND, Frances, E. [US/US]; (US).
DUFFY, David [GB/US]; (US).
GROGAN, Michael [US/US]; .
KATES, Steven [US/US]; (US).
OSTUNI, Emanuele [IT/US]; (US).
SCHUELLER, Olivier [FR/US]; (US).
SWEETNAM, Paul [US/US]; (US)
Inventors: LUND, Frances, E.; (US).
DUFFY, David; (US).
GROGAN, Michael; .
KATES, Steven; (US).
OSTUNI, Emanuele; (US).
SCHUELLER, Olivier; (US).
SWEETNAM, Paul; (US)
Agent: LAVENUE, Teresa, A.; KENYON & KENYON LLP, One Broadway, New York, NY 10004-1050 (US)
Priority Data:
60/654,519 18.02.2005 US
Title (EN) METHODS OF MAKING PHARMACOKINETICALLY IMPROVED COMPOUNDS COMPRISING FUNCTIONAL RESIDUES OR GROUPS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID COMPOUNDS
(FR) PROCEDES DE FABRICATION DE COMPOSES A AMELIORATION PHARMACOCINETIQUE COMPORTANT DES RESIDUS OU GROUPES FONCTIONNELS ET COMPOSITIONS PHARMACEUTIQUES COMPORTANT LESDITS COMPOSES
Abstract: front page image
(EN)The present invention relates to methods of modulating the pharmacokinetic and/or pharmacodynamic properties of a compound by attaching at least one functional unit or group to the compound, thereby improving its non-specific binding characteristics and/or pharmacokinetic properties. Compounds comprising at least one functional residue are provided, as are pharmaceutical compositions comprising said compounds.
(FR)La présente invention a trait à des procédés de modulation des propriétés pharmacocinétiques et/ou pharmacodynamiques d'un composé par la liaison d'au moins un motif ou groupe fonctionnel au composé, améliorant ainsi ses caractéristiques de liaison non spécifiques et/ou ses propriétés pharmacocinétiques. L'invention a trait à des composés comportant au moins un résidu fonctionnel et à des compositions pharmaceutiques comportant lesdits composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)