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Machine translation
1. (WO2006089268) GENE AND COGNATE PROTEIN PROFILES AND METHODS TO DETERMINE CONNECTIVE TISSUE MARKERS IN NORMAL AND PATHOLOGIC CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/089268    International Application No.:    PCT/US2006/005948
Publication Date: 24.08.2006 International Filing Date: 21.02.2006
IPC:
C07H 21/04 (2006.01), C12Q 1/68 (2006.01)
Applicants: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US/US]; 308 Bynum Hall, Campus Box 4105, Chapell Hill, North Carolina 27599-4105 (US) (For All Designated States Except US).
FLEXCELL INTERNATIONAL CORPORATION [US/US]; 437 Dimmocks Mill Road, Hillsborough, North Carolina 27278 (US) (For All Designated States Except US).
BANES, Albert [US/US]; (US) (For US Only).
QI, Jie [CN/US]; (US) (For US Only).
BYNUM, Donald [US/US]; (US) (For US Only).
KOLLER, Beverly [US/US]; (US) (For US Only).
THOMPSON, Jeffrey [US/US]; (US) (For US Only).
FOX, Ann [US/US]; (US) (For US Only).
NATION, Allison [US/US]; (US) (For US Only)
Inventors: BANES, Albert; (US).
QI, Jie; (US).
BYNUM, Donald; (US).
KOLLER, Beverly; (US).
THOMPSON, Jeffrey; (US).
FOX, Ann; (US).
NATION, Allison; (US)
Agent: TAYLOR, JR., Arles A.; Jenkins, Wilson, Taylor & Hunt, P.A., Suite 1200 University Tower, 3100 Tower Boulevard, Durham, North Carolina 27707 (US)
Priority Data:
60/654,232 18.02.2005 US
Title (EN) GENE AND COGNATE PROTEIN PROFILES AND METHODS TO DETERMINE CONNECTIVE TISSUE MARKERS IN NORMAL AND PATHOLOGIC CONDITIONS
(FR) PROFILS DE GENES ET DE PROTEINES APPARENTEES ET PROCEDES DE DETERMINATION DE MARQUEURS DE TISSU CONJONCTIF DANS DES CONDITIONS NORMALES ET PATHOLOGIQUES
Abstract: front page image
(EN)Differences in gene expression between connective tissue cells (e.g., tendon cells) and other closely related cell types are disclosed. Also disclosed are expression profiles between tendon cells under different genetic and environmental influences. The presently disclosed expression profiles are useful as diagnostic markers as well as markers that can be used to monitor disease states, disease progression, injury repair, drug toxicity, drug efficacy, and drug metabolism.
(FR)La présente invention a trait à l'expression génétique dans des cellules de tissus conjonctifs (par exemple, des cellules de tendons) et d'autres types de cellules intimement associés. L'invention a trait à des profils d'expression entre des cellules de tendons sous différentes influences génétiques et environnementales. Les profils d'expression de la présente invention sont utiles en tant que marqueurs diagnostiques et en tant que marqueurs pouvant être utilisés pour le suivi d'états morbides, de progression de maladies, de réparation de lésions, de toxicité de médicaments, d'efficacité de médicaments, et de métabolisme de médicaments.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)