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Machine translation
1. (WO2006089230) HUMAN MONOCLONAL ANTIBODIES TO PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/089230    International Application No.:    PCT/US2006/005852
Publication Date: 24.08.2006 International Filing Date: 17.02.2006
IPC:
C07K 16/28 (2006.01), A61P 13/08 (2006.01)
Applicants: MEDAREX, INC. [US/US]; 707 State Road, Princeton, New Jersey 08540 (US) (For All Designated States Except US).
HUANG, Haichun [US/US]; (US) (For US Only).
KING, David, John [US/US]; (US) (For US Only).
PAN, Chin [US/US]; (US) (For US Only).
CARDARELLI, Josephine, M. [US/US]; (US) (For US Only)
Inventors: HUANG, Haichun; (US).
KING, David, John; (US).
PAN, Chin; (US).
CARDARELLI, Josephine, M.; (US)
Agent: DECONTI, Giulio, A.; Lahive & Cockfield, LLP, One Post Office Square, Boston, MA 02109-2127 (US)
Priority Data:
60/654,125 18.02.2005 US
60/720,499 26.09.2005 US
60/748,417 08.12.2005 US
Title (EN) HUMAN MONOCLONAL ANTIBODIES TO PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA)
(FR) ANTICORPS MONOCLONAUX HUMAINS DIRIGES CONTRE L'ANTIGENE D'ENVELOPPE SPECIFIQUE DE LA PROSTATE
Abstract: front page image
(EN)The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PSMA with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecifÊc molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating cancer.
(FR)La présente invention concerne des anticorps monoclonaux isolés, notamment des anticorps monoclonaux humains qui se lient spécifiquement à l'antigène d'enveloppe spécifique de la prostate avec une forte affinité; des molécules d'acide nucléique qui codent les anticorps selon l'invention, des vecteurs d'expression, des cellules hôtes et des méthodes d'expression des anticorps selon l'invention; des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps selon l'invention; ainsi que des méthodes de traitement du cancer. .
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)