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Machine translation
1. (WO2006089221) COMPOUNDS INHIBITING THE AGGREGATION OF SUPEROXIDE DISMUTASE-1
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/089221    International Application No.:    PCT/US2006/005833
Publication Date: 24.08.2006 International Filing Date: 17.02.2006
IPC:
A61K 31/70 (2006.01), A01N 43/40 (2006.01), A01N 43/70 (2006.01)
Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US/US]; 75 Francis Street, Boston, Massachusetts 02115 (US) (For All Designated States Except US).
LANSBURY, Peter [US/US]; (US) (For US Only).
CHOI, Andrew [US/US]; (US) (For US Only).
RAY, Soumya [IN/US]; (US) (For US Only).
NOWAK, Richard [US/US]; (US) (For US Only)
Inventors: LANSBURY, Peter; (US).
CHOI, Andrew; (US).
RAY, Soumya; (US).
NOWAK, Richard; (US)
Agent: WALLER, Patrick, R., H.; Wolf, Greenfield & Sacks, P.C., 600 Atlantlic Avenue, Boston, MA 02210 (US)
Priority Data:
60/653,983 18.02.2005 US
11/354,896 16.02.2006 US
Title (EN) COMPOUNDS INHIBITING THE AGGREGATION OF SUPEROXIDE DISMUTASE-1
(FR) COMPOSES INHIBANT L'AGREGATION DE LA SUPEROXYDE DISMUTASE-1
Abstract: front page image
(EN)The invention is directed to methods of inhibiting the rate at which superoxide dismutse-1 (SOD) aggregates using compounds that stabilize SOD dimers. The methods are useful in the study and therapy of amyotrophic lateral sclerosis. The invention also includes assays that can be used to identify compounds that stabilize dimers and SOD molecules that have been modified for use in these assays.
(FR)L'invention concerne des méthodes permettant d'inhiber la vitesse à laquelle la superoxyde dismutase-1 (SOD) s'agrège à l'aide de composés qui stabilisent des dimères SOD. On utilise ces méthodes pour l'étude et la thérapie de la sclérose latérale amyotrophique. L'invention concerne également des dosages qui peuvent être utilisés pour identifier des composés qui stabilisent des dimères et des molécules SOD modifiés pour être utilisés dans lesdits dosages.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)