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1. (WO2006089177) ISOXAZOLE COMBRETASTIN DERIVATIVES FOR THE TREATMENT OF DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/089177    International Application No.:    PCT/US2006/005761
Publication Date: 24.08.2006 International Filing Date: 16.02.2006
Chapter 2 Demand Filed:    14.12.2006    
IPC:
C07D 261/08 (2006.01), C07D 413/04 (2006.01), A61K 31/42 (2006.01), A61P 35/00 (2006.01)
Applicants: SYNTA PHARMACEUTICALS CORP. [US/US]; 45 Hartwell Avenue, Lexington, Massachusetts 02421 (US) (For All Designated States Except US).
SUN, Lijun [CN/US]; (US) (For US Only).
BORELLA, Christopher [US/US]; (US) (For US Only).
LI, Hao [CN/US]; (US) (For US Only).
JIANG, Jun [CN/US]; (US) (For US Only).
CHEN, Shoujun [US/US]; (US) (For US Only).
KOYA, Keizo [JP/US]; (US) (For US Only).
INOUE, Takayo [JP/JP]; (JP) (For US Only).
DU, Zhenjian [US/US]; (US) (For US Only).
FOLEY, Kevin [US/US]; (US) (For US Only).
WU, Yaming [US/US]; (US) (For US Only).
ZHANG, Mei [CN/US]; (US) (For US Only).
YING, Weiwen [CN/US]; (US) (For US Only)
Inventors: SUN, Lijun; (US).
BORELLA, Christopher; (US).
LI, Hao; (US).
JIANG, Jun; (US).
CHEN, Shoujun; (US).
KOYA, Keizo; (US).
INOUE, Takayo; (JP).
DU, Zhenjian; (US).
FOLEY, Kevin; (US).
WU, Yaming; (US).
ZHANG, Mei; (US).
YING, Weiwen; (US)
Agent: DAVIS, Steven, G.; HAMILTON, BROOK, SMITH & REYNOLDS, P.C., 530 Virginia, P.o. Box 9133, Concord, Massachusetts 01742-9133 (US)
Priority Data:
60/653,890 17.02.2005 US
60/660,112 08.03.2005 US
60/733,912 04.11.2005 US
Title (EN) ISOXAZOLE COMBRETASTIN DERIVATIVES FOR THE TREATMENT OF DISORDERS
(FR) COMPOSES DE TRAITEMENT DE TROUBLES PROLIFERATIFS
Abstract: front page image
(EN)The invention relates to compounds of structural formula (I); or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
(FR)L'invention concerne des composés de la formule structurale (I) ou un sel, un solvate, un clathrate et un promédicament pharmaceutiquement acceptable de ceux-ci, dans laquelle Ra, Rb, et R2 ont la notation ci-définie. Ces composés inhibent la polymérisation de la tubuline et/ou ils ciblent le système vasculaire et sont utiles pour traiter les troubles prolifératifs tels que le cancer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)