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Machine translation
1. (WO2006089076) THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/089076    International Application No.:    PCT/US2006/005562
Publication Date: 24.08.2006 International Filing Date: 16.02.2006
IPC:
A61K 31/426 (2006.01), C07D 277/24 (2006.01), C07D 277/28 (2006.01)
Applicants: NEUROGEN CORPORATION [US/US]; 35 Northeast Industrial Road, Branford, Connecticut 06405 (US) (For All Designated States Except US).
PRINGLE, Wallace C. [US/US]; (US) (For US Only).
PETERSON, John M. [US/US]; (US) (For US Only).
XIE, Linghong [US/US]; (US) (For US Only).
GE, Ping [US/US]; (US) (For US Only).
GAO, Yang [CN/US]; (US) (For US Only).
OCHTERSKI, Joseph W. [US/US]; (US) (For US Only).
LAN, Jiong [CN/US]; (US) (For US Only)
Inventors: PRINGLE, Wallace C.; (US).
PETERSON, John M.; (US).
XIE, Linghong; (US).
GE, Ping; (US).
GAO, Yang; (US).
OCHTERSKI, Joseph W.; (US).
LAN, Jiong; (US)
Agent: KADLECEK, Ann; Neurogen Corporation, 35 Northeast Industrial Road, Branford, Connecticut 06405 (US)
Priority Data:
60/654,558 18.02.2005 US
60/720,500 26.09.2005 US
Title (EN) THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES
(FR) THIAZOLE AMIDES, IMIDAZOLE AMIDES ET ANALOGUES ASSOCIES
Abstract: front page image
(EN)Thiazole amides, imidazole amides and related analogues of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) and other disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).
(FR)L'invention porte sur des thiazole amides, des imidazole amides et les analogues associés de formule (I) dans laquelle: les variables sont définies dans la description. Ces composés peuvent moduler les ligands de fixant aux récepteurs de l'histamine H3 in vivo ou in vitro, sont particulièrement utiles pour traiter différents troubles du SNC, et autres chez l'homme, les animaux de compagnie et le bétail. Lesdits composés peuvent s'administrer seuls ou associés avec un ou des autres agents de traitement du SNC pour en potentialiser les effets. L'invention porte également sur des préparations pharmaceutiques et des méthodes de traitement de tels troubles et sur les méthodes d'utilisation de tels ligands en vue de la détection des récepteurs de l'histamine H3 (par exemple dans des études de localisation de ces récepteurs).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)