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1. (WO2006089043) COMPOSITIONS FOR ELICITING AN IMMUNE RESPONSE AGAINST MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/089043    International Application No.:    PCT/US2006/005509
Publication Date: 24.08.2006 International Filing Date: 16.02.2006
Chapter 2 Demand Filed:    15.09.2006    
IPC:
A61K 39/02 (2006.01), A61K 39/04 (2006.01), A61K 39/00 (2006.01), A01N 63/00 (2006.01), A61K 38/00 (2006.01)
Applicants: CORNELL RESEARCH FOUNDATION, INC. [US/US]; CORNELL BUSINESS AND TECHNOLOGY PARK, 20 Thornwood Drive, Suite 105, Ithaca, New York 14850 (US) (For All Designated States Except US).
CHANG, Yung-fu [US/US]; (US) (For US Only)
Inventors: CHANG, Yung-fu; (US)
Agent: LOPINSKI, John, D.; HODGSON RUSS LLP, The Guaranty Building, 140 Pearl Street, Suite 100, Buffalo, New York 14202-4040 (US)
Priority Data:
60/653,536 16.02.2005 US
Title (EN) COMPOSITIONS FOR ELICITING AN IMMUNE RESPONSE AGAINST MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS
(FR) COMPOSITIONS POUR DECLENCHER UNE REPONSE IMMUNITAIRE CONTRE DES SOUS-ESPECES DE MYCOBACTERIUM AVIUM DE PARATUBERCULOSIS
Abstract: front page image
(EN)The invention provides compositions and method for stimulating an immunological response against Mycobacterium avium subspecies paratuberculosis (MPT). The compositions comprise at least five recombinant immunogenic components. The immunogenic components can be MPT antigens or DNA polynucleotides encoding MPT antigens, or combinations thereof. MPT antigens used in the invention include MPT 85A, 85B, 85C, 35kDa, super oxide dismutase (SOD), MptC, MptD and ESAT-6 protein. The method comprises administering the composition to an animal in an amount effective to stimulate an immunological response against MPT bacteria. The method is of benefit to any animal susceptible to MPT infection, but is particularly beneficial for ruminants.
(FR)La présente invention a trait à des compositions et un procédé pour la stimulation d'une réponse immunologique contre des sous-espèces de Mycobacterium avium de paratuberculosis (MPT). Les compositions comprennent au moins cinq constituants immunogènes recombinants. Les constituants immunogènes recombinants peuvent être des antigènes MPT ou des polynucléotides d'ADN codant pour des antigènes MPT, ou des combinaisons de ceux-ci. Des antigènes MPT utilisés dans l'invention comprennent MPT 85A, 85B, 85C, 35kDa, la super oxyde dismutase, la protéine MptC, MptD et ESAT-6. Le procédé comprend l'administration de la composition à un animal en une quantité efficace pour stimuler une réponse immunologique contre des bactéries MPT. Le procédé est bénéfique à tout animal sensible à une infection MTP, mais est particulièrement bénéfique aux ruminants.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)