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Machine translation
1. (WO2006088921) PYRAZINYL SUBSTITUTED PIPERAZINE-PIPERIDINES WITH CXCR3 ANTAGONIST ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/088921    International Application No.:    PCT/US2006/005267
Publication Date: 24.08.2006 International Filing Date: 14.02.2006
IPC:
C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 405/14 (2006.01), C07D 413/14 (2006.01), C07D 417/14 (2006.01), A61K 31/445 (2006.01), A61K 31/495 (2006.01)
Applicants: SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road, Kenilworth, New Jersey 07033-0530 (US) (For All Designated States Except US).
PHARMACOPEIA, INC. [US/US]; 3000 Eastpark Boulevard, Cranbury, New Jersey 08512 (US) (For All Designated States Except US).
ROSENBLUM, Stuart, B. [US/US]; (US) (For US Only).
KIM, Seong, Heon [KR/US]; (US) (For US Only).
ZENG, Qingbei [CN/US]; (US) (For US Only).
WONG, Michael, K.C. [CA/US]; (US) (For US Only).
ANILKUMAR, Gopinadhan, N. [IN/US]; (US) (For US Only).
JIANG, Yueheng [CN/US]; (US) (For US Only).
YU, Wensheng [CN/US]; (US) (For US Only).
KOZLOWSKI, Joseph, A. [US/US]; (US) (For US Only).
SHIH, Neng-Yang [US/US]; (US) (For US Only).
SHANKAR, Bandarpalle, B. [US/US]; (US) (For US Only).
MCGUINNESS, Brian, F. [US/US]; (US) (For US Only).
DONG, Guizhen [US/US]; (US) (For US Only).
ZAWACKI, Lisa, Guise [US/US]; (US) (For US Only).
HOBBS, Douglas, W. [US/US]; (US) (For US Only).
BALDWIN, John, J. [US/US]; (US) (For US Only).
SHAO, Yuefei [CN/US]; (US) (For US Only)
Inventors: ROSENBLUM, Stuart, B.; (US).
KIM, Seong, Heon; (US).
ZENG, Qingbei; (US).
WONG, Michael, K.C.; (US).
ANILKUMAR, Gopinadhan, N.; (US).
JIANG, Yueheng; (US).
YU, Wensheng; (US).
KOZLOWSKI, Joseph, A.; (US).
SHIH, Neng-Yang; (US).
SHANKAR, Bandarpalle, B.; (US).
MCGUINNESS, Brian, F.; (US).
DONG, Guizhen; (US).
ZAWACKI, Lisa, Guise; (US).
HOBBS, Douglas, W.; (US).
BALDWIN, John, J.; (US).
SHAO, Yuefei; (US)
Agent: BANERJEE, Krishna, G.; Schering-plough Corporation, 2000 Galloping Hill Road, Patent Dept. K-6-1 1990, Kenilworth, New Jersey 07033-0530 (US)
Priority Data:
60/653,338 16.02.2005 US
Title (EN) PYRAZINYL SUBSTITUTED PIPERAZINE-PIPERIDINES WITH CXCR3 ANTAGONIST ACTIVITY
(FR) PIPERAZINE-PIPERIDINES PYRAZINYL SUBSTITUEES A ACTIVITE ANTAGONISTE DES CXCR3
Abstract: front page image
(EN)The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula (1): Chemical formula should be inserted here as it appears on the abstract in paper form. and the pharmaceutically acceptable salts, solvates and esters thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non limiting example(s) include, psoriasis), autoimmune diseases (non limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g., tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula (1).
(FR)La présente invention concerne un composé, ou des énantiomères, des stéréoisomères, des rotamères, des tautomères, des racémates ou un promédicament dudit composé, ou des sels pharmaceutiquement acceptables, des solvates ou des esters dudit composé, ou dudit promédicament, ledit composé présentant la structure générale présentée dans la formule (1), et les sels pharmaceutiquement acceptables, les solvates et les esters du ce dernier. L'invention concerne également une méthode de traitement de maladies médiées par les chimiokines, telle que le traitement palliatif, le traitement curatif, le traitement prohylactique de certaines maladies et pathologies telles que les maladies inflammatoires (un exemple non exhaustif comprenant le psoriasis), les maladies autoimmunes (des exemples non exhaustifs comprenant la polyarthrite rhumatoïde, la sclérose en plaques), le rejet de greffe (des exemples non exhaustifs comprenant le rejet d'allogreffe, le rejet de xénogreffe), les maladies infectieuses par exemple, la lèpre tuberculoïde), les éruptions fixes d'origine médicamenteuse, les réactions d'hypersensibilité retardée cutanée, l'inflammation ophtalmique, le diabète de type I, la méningite virale et les tumeurs à l'aide d'un composé de formule (1).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)