WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2006088823) METHOD FOR DETECTING MISFOLDED PROTEINS AND PRIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/088823    International Application No.:    PCT/US2006/005095
Publication Date: 24.08.2006 International Filing Date: 14.02.2006
Chapter 2 Demand Filed:    30.04.2007    
IPC:
G01N 33/53 (2006.01), G01N 33/566 (2006.01), C07K 17/00 (2006.01), B01L 3/00 (2006.01)
Applicants: ADLYFE, INC. [US/US]; 9430 Key West Avenue, Suite 210, Rockville, MD 20850 (US) (For All Designated States Except US).
ORSER, Cindy, S. [US/US]; (US) (For US Only).
PAN, Tao [CN/US]; (US) (For US Only).
SETHI, Jasmeet [GB/US]; (US) (For US Only)
Inventors: ORSER, Cindy, S.; (US).
PAN, Tao; (US).
SETHI, Jasmeet; (US)
Agent: SIMKIN, Michele, M.; Foley & Lardner LLP, 3000 K Street N.W., Suite 500, Washington, DC 20007-5143 (US)
Priority Data:
60/652,733 15.02.2005 US
Title (EN) METHOD FOR DETECTING MISFOLDED PROTEINS AND PRIONS
(FR) PROCEDE DE DETECTION DE PROTEINES ET DE PRIONS A REPLIEMENT INCORRECT
Abstract: front page image
(EN)The invention provides methods and kits for detecting conformationally altered proteins, such as prions or other proteins associated with disease states, in a sample. The methods comprise selectively capturing and separating complexes of peptide and conformationally altered protein from substances that interfere with detection of such complexes, and preferably amplification of the detection signal b addition of a second double-labeled peptide.
(FR)La présente invention a trait à des procédés et des trousses pour la détection de protéines à altération conformationnelle, tels que des prions et autres protéines associés à des états morbides, dans un échantillon. Les procédés comprennent la capture sélective et la séparation de complexes de peptide et de protéine à altération conformationnelle à partir de substances qui entravent la détection de tels complexes, et de préférence l'amplification de la détection de signal par l'ajout d'un deuxième peptide à double marqueur.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)