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Pub. No.:    WO/2006/088541    International Application No.:    PCT/US2005/044978
Publication Date: 24.08.2006 International Filing Date: 12.12.2005
A61K 31/55 (2006.01), A61K 31/54 (2006.01), A61K 31/497 (2006.01), A61K 31/44 (2006.01), A61K 31/47 (2006.01), A61P 33/06 (2006.01), C07D 243/08 (2006.01), C07D 223/18 (2006.01), C07D 279/24 (2006.01), C07D 417/00 (2006.01), C07D 401/00 (2006.01), C07D 221/00 (2006.01), C07D 219/12 (2006.01), C07D 215/00 (2006.01)
Applicants: STATE OF OREGON ACTING BY & THROUGH THE STATE BOARD OF HIGHER EDU. ON BEHALF OF PORTLAND STATE UNV. [US/US]; P.o. Box 751, Portland, Oregon 97207 (US) (For All Designated States Except US).
PEYTON, David, H. [US/US]; (US) (For US Only).
BURGESS, Steven [US/US]; (US) (For US Only)
Inventors: PEYTON, David, H.; (US).
BURGESS, Steven; (US)
Agent: YOUNG, Travis; KLARQUIST SPARKMAN, LLP, ONE WORLD TRADE CENTER, SUITE 1600, 121 Sw Salmon Street, Portland, Oregon 97204 (US)
Priority Data:
60/654,207 17.02.2005 US
Abstract: front page image
(EN)This disclosure provides a new class of compounds referred to as 'reversed chloroquines' (RCQs), which are highly effective against CQR and CQS malaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog (such as chloroquine) moiety and a CQR reversal moiety. Exemplary RCQ chemical structures are provided. Also provided are pharmaceutical compositions including the disclosed RCQ compounds, and methods of using such compounds and compositions for the treatment of malaria and inhibition of CQR or CQS Plasmodium sp. (such as P. falciparum).
(FR)Classe de composés appelés 'chloroquines inversées', très efficaces contre les parasites du paludisme résistant à la chloroquine (CQR) et sensibles à la chloroquine (CQS). Il s'agit de molécules hybrides, qui renferment une fraction d'analogue de quinoline antipaludique (du type chloroquine) et une fraction d'inversion de CQR. On cite des exemples de structures chimiques de ces chloroquines. Enfin, l'invention concerne des compositions pharmaceutiques renfermant les composés considérés, et des procédés relatifs à l'utilisation des composés et compositions en question pour le traitement du paludisme et l'inhibition de Plasmodium sp. (du type P. falciparum) CQR ou CQS.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)