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1. (WO2006088219) IL-13 PRODUCTION INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/088219    International Application No.:    PCT/JP2006/303099
Publication Date: 24.08.2006 International Filing Date: 15.02.2006
IPC:
C12N 15/09 (2006.01), A61K 45/00 (2006.01), A61P 1/04 (2006.01), A61P 3/06 (2006.01), A61P 9/04 (2006.01), A61P 11/00 (2006.01), A61P 13/12 (2006.01), A61P 19/02 (2006.01), A61P 29/00 (2006.01), A61P 37/08 (2006.01), C12N 5/10 (2006.01), G01N 33/15 (2006.01), A61K 31/7088 (2006.01), A61K 48/00 (2006.01), A61P 1/16 (2006.01), A61P 3/10 (2006.01), A61P 9/06 (2006.01), A61P 11/06 (2006.01), A61P 15/00 (2006.01), A61P 21/04 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01), C12Q 1/02 (2006.01), G01N 33/50 (2006.01), A61K 39/395 (2006.01), A61P 1/00 (2006.01), A61P 3/04 (2006.01), A61P 9/00 (2006.01), A61P 9/10 (2006.01), A61P 13/00 (2006.01), A61P 17/00 (2006.01), A61P 27/16 (2006.01), A61P 37/02 (2006.01), C12N 5/06 (2006.01), C12Q 1/48 (2006.01), G01N 33/53 (2006.01)
Applicants: TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410045 (JP) (For All Designated States Except US).
OGI, Kazuhiro [JP/JP]; (JP) (For US Only).
KIKUKAWA, Yusuke [JP/JP]; (JP) (For US Only).
SUGO, Tsukasa [JP/JP]; (JP) (For US Only).
SHINOHARA, Tokuyuki [JP/JP]; (JP) (For US Only)
Inventors: OGI, Kazuhiro; (JP).
KIKUKAWA, Yusuke; (JP).
SUGO, Tsukasa; (JP).
SHINOHARA, Tokuyuki; (JP)
Agent: KOBAYASHI, Hiroshi; c/o ABE, IKUBO & KATAYAMA, Fukuoka Bldg. 9th Fl., 8-7, Yaesu 2-chome, , Chuo-ku, Tokyo 1040028 (JP)
Priority Data:
2005-038859 16.02.2005 JP
Title (EN) IL-13 PRODUCTION INHIBITOR
(FR) INHIBITEUR DE PRODUCTION D’IL-13
(JA) IL-13産生抑制剤
Abstract: front page image
(EN)A method/kit for screening an IL-13 production inhibitor using (a) a protein comprising an amino acid sequence identical or substantially identical to the amino acid sequence depicted in SEQ ID No:1 or a partial peptide of the protein or a salt thereof; and (b) a ligand capable of specifically binding to the protein; an IL-13 production inhibitor given by the screening; and the like. The IL-13 production inhibitor which can be given by the screening is useful as a prophylactic/therapeutic agent for a respiratory disease or the like.
(FR)L’invention concerne un procédé/kit pour le criblage d’un inhibiteur de la production d’IL-13 en utilisant (a) une protéine comprenant une séquence d'acide aminé identique ou sensiblement identique à la séquence d'acide aminé décrite par SEQ ID No:1 ou un peptide partiel de la protéine ou un sel de celui-ci ; et (b) un ligand capable de se lier spécifiquement à la protéine ; un inhibiteur de la production d’IL-13 obtenu par le criblage ; et analogue. L'inhibiteur de la production d’IL-13 qui peut être obtenu par le criblage est utile en tant qu’agent prophylactique/thérapeutique contre une maladie respiratoire ou analogue.
(JA)本発明は、(a)配列番号:1で表されるアミノ酸配列と同一もしくは実質的に同一のアミノ酸配列を含有する蛋白質もしくはその部分ペプチドまたはその塩および(b)該蛋白質と特異的に結合する能力を有するリガンドを用いることを特徴とする、IL-13産生阻害剤のスクリーニング方法/スクリーニング用キット、該スクリーニングによって得られるIL-13産生阻害剤などを提供する。本発明のスクリーニングによって得られうるIL-13産生阻害剤は、例えば、呼吸器疾患などの予防・治療剤などとして有用である。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)